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Rose Kohlie Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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Nina Perwitz Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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Julia Resch Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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Sebastian M Schmid Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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Hendrik Lehnert Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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Johannes Klein Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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K Alexander Iwen Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Medizinische Klinik I, Lübeck, Germany

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intracellular third messenger for DA, in BAT of pigs suggests a direct role of DA in brown adipocytes ( Meister et al . 1988 ). DA receptors appear to be present in BAT homogenates obtained from rats, as suggested by the response of AC to various DA receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0159
Volume/Issue:
Volume 58: Issue 2
Free access
Juan Liu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Xiaocen Kong Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Long Wang Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Hanmei Qi Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Wenjuan Di Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Xiao Zhang Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Lin Wu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Xia Chen Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Jing Yu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Juanmin Zha Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Shan Lv Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Aisen Zhang Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Peng Cheng Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Miao Hu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Yujie Li Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Jianhua Bi Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Yan Li Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Fang Hu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Yi Zhong Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Yong Xu Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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Guoxian Ding Department of Gerontology, Departments of Pathophysiology, Preventive Medicine, Department of Pharmaceutical Chemistry, Metabolic Syndrome Research Center of Central South University, First Hospital Affiliated to Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

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are specialized in energy preservation in the form of triglycerides. However, adipose tissue also contains another type of fat cells called ‘brown adipocyte’. By contrast to white adipose tissue (WAT), brown adipose tissue (BAT) plays an active role in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0099
Volume/Issue:
Volume 50: Issue 1
Free access
S Viengchareun
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H Bouzinba-Segard
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J-P Laigneau
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M-C Zennaro
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P A Kelly
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A Bado
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M Lombès
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N Binart
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rats. Moreover, we have recently shown that brown adipocytes are also endocrine cells able to secrete leptin ( Buyse et al. 2001 ) and other adipocytokines such as resistin and adiponectin, two adipocyte-specific secretory factors involved in glucose

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01563
Volume/Issue:
Volume 33: Issue 3
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Raquel Martinez-deMena Unidad de Endocrinología Molecular, Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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Maria-Jesus Obregón Unidad de Endocrinología Molecular, Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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specific marker of BAT. In floating brown adipocytes, D2 is stimulated by adrenergic agents ( Obregón et al. 1987 ), and synergism between the α1 and β adrenergic pathways has been described ( Raasmaja & Larsen 1989 ). In addition, BAT D2

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01568
Volume/Issue:
Volume 34: Issue 1
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Susan M van den Berg Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Andrea D van Dam Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Pascal J H Kusters Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Linda Beckers Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Myrthe den Toom Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Saskia van der Velden Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Jan Van den Bossche Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Irma van Die Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

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Mariëtte R Boon Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Patrick C N Rensen Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Esther Lutgens Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany

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Menno P J de Winther Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany

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Introduction Brown adipose tissue (BAT) contributes to the control of body temperature by the production of heat in response to cold. Brown adipocytes have numerous mitochondria that contain uncoupling protein 1 (UCP1). Activation of brown

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0112
Volume/Issue:
Volume 59: Issue 3
Free access
Stefania Carobbio Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Barry Rosen Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Antonio Vidal-Puig Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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method of obtaining human brown adipocytes from human BAT is through biopsies, which tend to be both small and surgically difficult to obtain, giving access to a very limited numbers of cells. This limits the possibilities for investigating human BAT

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0158
Volume/Issue:
Volume 51: Issue 3
Free access
Rui Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Jie Hong Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Ruixin Liu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Maopei Chen Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Min Xu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Wiqiong Gu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Yifei Zhang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Qinyun Ma Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Feng Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Juan Shi Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Jiqiu Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Weiqing Wang Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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Guang Ning Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Laboratory for Endocrine and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

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metabolic dysfunction, Ehrlund et al . (2013) indicated that SFRP5 in the WAT of Caucasians is not influenced by obesity. In light of the profound but conflicting effects of SFRP5 on adipogenesis and its unknown effect on brown adipocyte differentiation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0037
Volume/Issue:
Volume 53: Issue 3
Free access
Daiana Araujo Santana-Oliveira Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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Aline Fernandes-da-Silva Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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Carolline Santos Miranda Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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Fabiane Ferreira Martins Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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Carlos Alberto Mandarim-de-Lacerda Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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Vanessa Souza-Mello Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

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photomicrographs ( Fig. 4A ) show brown adipocytes that resemble unilocular white adipocytes in the HF group, and the whitening phenomenon contrasts with the multilocular brown adipocytes in the C group. The HF group showed increased BAT mass/g BM (+33%, Table 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0084
Volume/Issue:
Volume 68: Issue 4
Restricted access
Kasiphak Kaikaew Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Aldo Grefhorst Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Department of Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands

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Jacobie Steenbergen Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Sigrid M A Swagemakers Department of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Anke McLuskey Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Jenny A Visser Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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). Treatment of cultured brown adipocytes with sex steroids confirmed that E2 facilitates while testosterone inhibits NE-induced lipolysis, an initial step of BAT thermogenesis ( Monjo et al. 2003 ). While sex steroids may control BAT thermogenic activity

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0210
Volume/Issue:
Volume 66: Issue 2
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Andrew Whittle Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

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. Canonical regulation is via the SNS. Of particular interest is the fact that many of the recently characterised molecules signal through specific receptors to enhance the capacity of brown adipocytes to respond to adrenergic stimulation. The range of tissues

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-12-0080
Volume/Issue:
Volume 49: Issue 2
Free access