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Stefania Carobbio Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Barry Rosen Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Antonio Vidal-Puig Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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foci within WAT depots are in fact brite cells. However, despite their similarities with canonical BAT, brite adipocytes also have specific gene expression patterns that are different from those of both white and canonical brown adipocytes. It is of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0158
Volume/Issue:
Volume 51: Issue 3
Free access
Susan M van den Berg Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Andrea D van Dam Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Pascal J H Kusters Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Linda Beckers Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Myrthe den Toom Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Saskia van der Velden Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Jan Van den Bossche Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Irma van Die Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

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Mariëtte R Boon Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Patrick C N Rensen Department of Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Esther Lutgens Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany

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Menno P J de Winther Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University, Munich, Germany

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BAT by repetitive cold exposure enhances energy expenditure and lowers fat mass ( van der Lans et al . 2013 , Yoneshiro et al . 2013 ), underscoring the role of BAT in energy metabolism in humans. Brown-like or ‘beige/brite’ adipocytes can also be

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0112
Volume/Issue:
Volume 59: Issue 3
Free access
Varun S Venkatesh Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Patricia K Russell Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Barbara Fam White Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Michele V Clarke Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Suzanne Golub Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Salvatore Mangiofico Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Christian Haralambous Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Julie Lokan Department of Anatomical Pathology, Austin Health, Heidelberg, Victoria, Australia

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Sof Andrikopoulos Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Jeffrey D Zajac Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Rachel A Davey Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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via beiging of WAT; that is the presence of multiocular adipocytes that express UCP1 and resemble brown adipocytes (also referred to as ‘brite’ adipocytes) ( Petrovic et al. 2010 ). We have previously shown that the AR transgene in PC-AR Gene

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0038
Volume/Issue:
Volume 69: Issue 1
Restricted access
Junye Chen Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Nanchang Joint Programme, Queen Mary, University of London, London, UK

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Yi Lu Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China

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Mengyuan Tian Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Nanchang Joint Programme, Queen Mary, University of London, London, UK

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Qiren Huang Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China

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. 2012 ). Currently, scientists term it ‘beige’ or ‘brite’ adipocytes, which are generally considered as a middle state between the white and brown adipocytes ( Wu et al. 2012 , Harms & Seale 2013 ). The transcription factor FOXO family comprises

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0178
Volume/Issue:
Volume 62: Issue 3
Free access