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Wenhui Su and Xinchun Liu

Introduction In mammals, the blood–testis barrier (BTB) that divides the seminiferous epithelium into the basal and the adluminal (apical) compartment provides an independent environment for the development of meiosis I/II and postmeiotic spermatid

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Wing-Yee Lui and Will M Lee

, neighboring Sertoli cells closely associate with each other to form the blood–testis barrier (BTB) that is constituted by inter-Sertoli tight junctions (TJ) and basal ectoplasmic specializations (ES, an atypical adherens junction (AJ) type). The BTB is

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Ariane Zamoner, Kátia Padilha Barreto, Danilo Wilhelm Filho, Fabíola Sell, Viviane Mara Woehl, Fátima Costa Rodrigues Guma, Regina Pessoa-Pureur and Fátima Regina Mena Barreto Silva

pivotal role in the regulation and maintenance of spermatogenesis and are the site of action of all hormonal influences modulating testis development. They also provide physical support to germ cells, form the blood–testis barrier, and secrete protein

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María Noel Galardo, María Fernanda Riera, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga and Silvina Beatriz Meroni

cells are absolutely necessary in order to provide an adequate and protected environment within the seminiferous tubules. Germ cells situated beyond the blood testis barrier need to rely on Sertoli cell production of factors that fuel germ cell

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Marcel E Dinger, Timothy R Mercer and John S Mattick

, Rassoulzadegan et al . 2006 , Chandler 2007 ). This process can be directed by miRNAs as well as other small RNAs and appears to require the action of the RNA methyltransferase Dnmt2 ( Cuzin 2007 ). Similar to the blood–brain barrier, the blood–testis barrier