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Andrew B Bicknell School of Biological Sciences, University of Reading, Whiteknights, Reading, UK

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processing of different variants of human POMC ( Morris et al. 1995 ), but after about a year, the project shifted sideways into investigating the mechanisms by which POMC peptides regulate adrenal growth. I have worked in this area ever since

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0269
Volume/Issue:
Volume 56: Issue 4
Free access
Namita G Hattangady Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Shigehiro Karashima Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA

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Lucy Yuan Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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Daniela Ponce-Balbuena Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

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José Jalife Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA

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Celso E Gomez-Sanchez G. V. (Sonny) Montgomery VA Medical Center and Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA

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Richard J Auchus Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA

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William E Rainey Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA

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Tobias Else Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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represents the most common cause of secondary hypertension. The main causes of PA are aldosterone-producing adenomas (APA) and bilateral adrenal hyperplasia. In 2011, Choi and colleagues reported muta­tions in the selectivity filter of the inward-rectifying K

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0324
Volume/Issue:
Volume 57: Issue 1
Free access
Adrian J L Clark Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK

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mRNA expression in nonpituitary tissues including testis, ovary, placenta, lung, liver, thyroid and adrenal ( Chen et al. 1984 , 1986 , Pintar et al. 1984 , Lolait et al. 1986 , DeBold et al. 1988 b ). Surprisingly, the mRNA in these tissues

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0268
Volume/Issue:
Volume 56: Issue 4
Free access
Philip Lowry Emeritus Professor School of Biological Sciences, University of Reading, Reading, UK

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(CLIP), pro-γ-MSH and big γ-MSH and their involvement in corticosteroidogenesis and adrenal growth, and speculate on their secretion from the zona imtermedia and roles in the development of both the foetal adrenal and prepubertal reticularis zones. I

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0260
Volume/Issue:
Volume 56: Issue 4
Free access
Matthew Stagl Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Mary Bozsik Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Christopher Karow Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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David Wertz Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Ian Kloehn Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Savin Pillai Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Paul J Gasser Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Marieke R Gilmartin Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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Jennifer A Evans Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin, USA

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changes in the release of adrenocorticotrophic hormone (ACTH) and adrenal sensitivity to ACTH. Daily rhythms in both of these factors are driven by the circadian timekeeping system ( Son et al . 2011 , Nicolaides et al . 2017 ), which is a hierarchical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0146
Volume/Issue:
Volume 60: Issue 2
Free access
Nicole Gallo-Payet Division of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
Division of Endocrinology, Department of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada

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-MSH) (a.a. 1–13 of ACTH) ( Raffin-Sanson et al. 2003 , Dores et al. 2014 ). ACTH is mainly produced in the corticotropic cells from the anterior pituitary, but is also produced in the brain, adrenal medulla, skin, and placenta ( Vrezas et al. 2003

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0257
Volume/Issue:
Volume 56: Issue 4
Free access
Alexander Dierks Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Urs D Lichtenauer Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany
Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Simone Sackmann Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Ariadni Spyroglou Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Igor Shapiro Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany
Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Marcel Geyer Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Jenny Manonopoulou Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Martin Reincke Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Constanze Hantel Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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Felix Beuschlein Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany
Endocrine Research Unit, Institute of Molecular Medicine and Cell Research, Department of Internal Medicine IV, Medizinische Klinik-Innenstadt, Ludwig-Maximilians-University, Ziemssenstr. 1, D-80336 Munich, Germany

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. 2004 ), the molecular mechanisms that contribute to autonomous aldosterone secretion only begin to emerge. Aldosterone is released by the cells of the adrenal zona glomerulosa, but stored only in minimal quantities. Thus, ad hoc biosynthesis of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0171
Volume/Issue:
Volume 45: Issue 4
Free access
Inga K Johnsen Department of Medicine, Endocrine Research, University Hospital Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany

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Felix Beuschlein Department of Medicine, Endocrine Research, University Hospital Innenstadt, Ludwig Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany

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number of hormonal systems. In this review, we will specifically highlight novel aspects of BMP-dependent regulatory networks that pertain to adrenal physiology and disease, which have been uncovered during recent years. BMPs in adrenal development BMPs

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0001
Volume/Issue:
Volume 44: Issue 4
Free access
Andreas Hoeflich
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Maximilian Bielohuby Laboratory of Mouse Genetics, Neuroendocrine Unit, Research Unit Genetics and Biometry, Research Institute for the Biology of Farm Animals, FBN Dummerstorf, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Introduction In mammals, the adrenal cortex and medulla are formed during embryogenesis by two distinct cell populations deriving from mesodermal and neuroectodermal origins ( Hammer et al . 2005 ). Both cell populations are encapsulated before

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0160
Volume/Issue:
Volume 42: Issue 3
Free access
Philippe Huber Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Christine Mallet Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Elodie Faure Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Christine Rampon Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Marie-Hélène Prandini Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Olivier Féraud Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Stéphanie Bouillot Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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Isabelle Vilgrain Laboratoire Développement et Vieillissement de l’Endothelium, INSERM EMI 02-19, DRDC/DVE, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
INSERM EMI 01-05, Department of Cellular Responses and Dynamics, CEA, Grenoble, France

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)-induced survival pathway ( Carmeliet et al. 1999 ). The steroidogenic adrenal gland is an endocrine tissue characterised by an intense capillary network of highly permeable, often fenestrated vessels that allows the transportation of the endocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01641
Volume/Issue:
Volume 34: Issue 1
Free access