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Xinwang Chen, Xiao Jia, Jie Qiao, Youfei Guan and Jihong Kang

variety of bioactive cytokines named adipokines. Adipokines comprise both adipose-specific cytokines or cytokines predominantly secreted by adipocytes, such as leptin, resistin, adiponectin (APN), visfatin, and omentin, and nonadipose-specific cytokines

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Hui Juan Zhu, Hui Pan, Xu Zhe Zhang, Nai Shi Li, Lin Jie Wang, Hong Bo Yang and Feng Ying Gong

lipid metabolism enzymes and adipokines in 3T3-L1 cells. Materials and methods Cell culture and differentiation Preadipocyte 3T3-L1 (ATCC, Manassas, VA, USA) cells were cultured in DMEM/F12 (Invitrogen) supplemented with 10% (v/v) fetal bovine serum (FBS

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Rodolfo Gomez, Francisca Lago, Juan Gomez-Reino, Carlos Dieguez and Oreste Gualillo

16 kDa protein is the product of the gene obese ( ob ), which is mutated in a murine form of hereditary obesity. Since then, WAT has been found to generate more than 50 cytokines and other molecules ( Rasouli & Kern 2008 ). These ‘adipokines’ exert

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Umberto Bernabucci, Loredana Basiricò, Patrizia Morera, Nicola Lacetera, Bruno Ronchi and Alessandro Nardone

. 2002 ). Animal and human data demonstrate that hypoadiponectinemia and hyperleptinemia associated with a deregulation of genes expression of these adipokines play a central role in the genesis of the CVD, obesity, and diabetes risk factor ( Arita et al

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Anthony H Tsang, Johanna L Barclay and Henrik Oster

well as in genetically obese mice such as ob/ob (lacking the leptin gene) and KK-A(y) mice (a spontaneous diabetic mouse model). However, arguably the most dramatic effects of HFD and obesity are the effects seen on circulating adipokines such as

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Jung Ok Lee, Nami Kim, Hye Jeong Lee, Yong Woo Lee, Joong Kwan Kim, Hyung Ip Kim, Soo Kyung Lee, Su Jin Kim, Sun Hwa Park and Hyeon Soo Kim

characterized as a new adipokine that is mainly expressed in and secreted from visceral fat rather than subcutaneous fat. Visfatin exerts insulin-mimetic effects in stimulating muscle and adipocyte glucose transport and in inhibiting hepatocyte glucose

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Patrizia Morera, Loredana Basiricò, Kenji Hosoda and Umberto Bernabucci

temperature rather than indirect factors, such as the reduction of feed intake. Two adipokines, leptin and adiponectin, are metabolically relevant in coordinating energy homeostasis ( Ailhaud 2006 ). Leptin affects energy homeostasis by decreasing food intake

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Jiazhong Sun, Yancheng Xu, Haohua Deng, Suxin Sun, Zhe Dai and Yanlei Sun

Introduction Adipose tissue is a major endocrine organ, which releases a wide range of protein signals and factors termed adipokines. A number of adipokines, including leptin, adiponectin, resistin, plasminogen activator inhibitor-1, are linked to

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Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa and Norimasa Sagawa

adipose tissue also occurs in late pregnancy, pregnant mice were used to examine adipocyte size, the changes in the infiltration of M1 and M2 macrophages, serum adipokine levels, and the gene expression of adipokines in subcutaneous adipose tissue (SAT

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Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu and Bo Yu

humans is an independent risk factor for myocardial infarction, stroke and type 2 diabetes mellitus ( Hubert et al. 1983 , Kurth et al. 2002 ). Adipocytes can secrete a number of factors, named adipokines, into other tissues, and participate in a