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Caroline M Gorvin

et al . 2016 , 2017 a , Piret et al . 2016 ). FHH type-3 (FHH3) is due to mutations in the sigma subunit of the adaptor protein-2 (AP2σ), which plays a fundamental role in clathrin-mediated endocytosis of transmembrane proteins, such as GPCRs

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Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

– 371 . ( doi:10.1016/j.beem.2013.04.007 ) Hannan FM Howles SA Rogers A Cranston T Gorvin CM Babinsky VN Reed AA Thakker CE Bockenhauer D Brown RS 2015a Adaptor protein-2 sigma subunit mutations causing

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Yiyan Wang, Xiaoheng Li, Fei Ge, Kaiming Yuan, Zhijian Su, Guimin Wang, Qingquan Lian and Ren-Shan Ge

317 ± 29 301 ± 7 (1) 1466 ± 33 (5)*  Ier2 Immediate early response 2 297 ± 17 442 ± 11 (2) 1202 ± 17 (4)*  Sh2b2 SH2B adaptor protein 2 34 ± 1 78 ± 4 (2) 133 ± 4 (4)*  Dclk2 Doublecortin-like kinase 2 18 ± 4

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J Jason Collier, Tim E Sparer, Michael D Karlstad and Susan J Burke

.08.005 ) Raman D Sai J Hawkins O Richmond A 2014 Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration . Traffic 15 451 – 469 . ( doi:10.1111/tra.12154 ) Rehman KK Bertera S Bottino R Balamurugan AN Mai JC

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Caroline M Gorvin

protein, by which CaSR signals, and the adaptor protein-2 sigma subunit (AP2σ), by which CaSR is internalized, revealed as additional contributors to calcaemic disorders. Studies of these mutations have uncovered novel mechanisms by which CaSR is