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Samantha Gardner, Emmanouil Stavrou, Patricia E Rischitor, Elena Faccenda and Adam J Pawson

signalling can lead to a range of diseases, most notably cancer ( Polakis 2000 ). The canonical Wnt/β-catenin pathway is perhaps the best described Wnt signalling pathway. The key effector of this pathway is β-catenin. In the absence of Wnt ligand (19 family

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Su M Hlaing, Leah A Garcia, Jaime R Contreras, Keith C Norris, Monica G Ferrini and Jorge N Artaza

. 2007 ). The aim of this study was to test the hypothesis that 1,25-D 3 promotes myocardiac cell differentiation through inhibition of the WNT signaling pathway and to determine the associated molecular mechanism(s) in a well-known and widely used heart

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Rui Wang, Jie Hong, Ruixin Liu, Maopei Chen, Min Xu, Wiqiong Gu, Yifei Zhang, Qinyun Ma, Feng Wang, Juan Shi, Jiqiu Wang, Weiqing Wang and Guang Ning

canonical and non-canonical WNT signalling pathways ( Li et al . 2008 , Satoh et al . 2008 ) and might be an import metabolic regulator ( Ouchi et al . 2010 , Mori et al . 2012 , Carstensen et al . 2014 ). Results from an in vitro study indicated

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Changgui Shi, Ping Huang, Hui Kang, Bo Hu, Jin Qi, Min Jiang, Hanbing Zhou, Lei Guo and Lianfu Deng

. 2012 , Ma et al . 2012 , Wei et al . 2012 , Xu et al . 2012 a , b , Chiyomaru et al . 2013 , Wu et al . 2013 ). Moreover, these six miRNAs have been reported to regulate the WNT signaling pathway ( Chiyomaru et al . 2013 , Liu et al . 2013

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Gill Holdsworth, Scott J Roberts and Hua Zhu Ke

amount of research into its biology. Sclerostin is now understood to act as an antagonist of the canonical WNT signalling pathway in osteoblast lineage cells, thereby negatively regulating bone formation. Inhibition of sclerostin has been proposed as a

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Kathryn L Auld, Stephen P Berasi, Yan Liu, Michael Cain, Ying Zhang, Christine Huard, Shoichi Fukayama, Jing Zhang, Sung Choe, Wenyan Zhong, Bheem M Bhat, Ramesh A Bhat, Eugene L Brown and Robert V Martinez

upregulation of these genes by ERRα+PGC-1α could involve Wnt-signaling pathway(s), we next compared these data with the set of genes significantly changing when cells are treated with WNT3A over-expression. Significant overlap was observed between genes

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Matthias Laudes

2004 ). WNT molecules exert their effects by signalling through different ‘canonical’ and ‘non-canonical’ pathways ( Fig. 1 ). The canonical WNT signalling pathway is also referred to as ‘WNT/β-catenin dependent’ and the non-canonical pathway as ‘WNT

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Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong-Ping Feng, M Cristina Nostro and Tianru Jin

explore functions of this Wnt signaling pathway effector in pancreatic β-cells and elsewhere ( Schafer et al . 2007 , Norton et al . 2011 , 2014 , Ip et al . 2012 , 2015 , Kaminska et al . 2012 , Jin 2016 ). Previous in vitro and ex vivo

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Ke-feng Yang, Wei Cai, Jia-li Xu and Wen Shi

nutritional programming on liver metabolism and gene expression ( Brameld et al . 2000 , Buckley et al . 2005 ). As a critical regulator of liver development, the Wnt signaling pathway is essential for embryonic liver development, postnatal liver growth

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I J Bujalska, M Quinkler, J W Tomlinson, C T Montague, D M Smith and P M Stewart

and WARS ), oncogenes ( ENPP2 ), anti-apoptotic ( OXTR ). Interestingly, in SC preadipocytes F-treatment decreased expression of two genes associated with Wnt-signalling pathways ( FZD7 and SFRP4 ; 3.5- and 3.3-fold respectively; Fig. 3