Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher BMI values. Although these data are supported by many clinical and epidemiological studies, our knowledge is very scarce at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling downregulates the expression of thyroid-specific transcription factor 2 (TTF-2/FoxE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FoxE1 gene expression is mediated by adipocyte signaling.
Michela Zamboni, Georgios Strimpakos, Eleonora Poggiogalle, Lorenzo M Donini, and Donato Civitareale
Cinzia Puppin, Nadia Passon, Jerome M Hershman, Sebastiano Filetti, Stefania Bulotta, Marilena Celano, Diego Russo, and Giuseppe Damante
cooperation between SAHA and VPA is specific for NIS gene, effects of HDACi on other genes were investigated. Transcript levels of PAX8 , TTF-1 ( NKX2-1 ), TTF-2 ( FOXE1 ) CREM , TSHR , TPO , APE-REF1 ( APEX1 ), ASF/SF2 ( SRSF1 ) and Periostin