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Pabitra B Pal, Himangshu Sonowal, Kirtikar Shukla, Satish K Srivastava and Kota V Ramana

improve endothelial function and protection against endothelial dysfunction in various pathologies. The NAD + -dependent histone deacetylases such as Sirt1 have attained considerable attention as an important metabolic regulator of hyperglycemia

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Huixia Li, Zhuanmin Zhang, Dongxu Feng, Lin Xu, Fang Li, Jiali Liu, Xinxin Jin, Zhuang Qian, Xiaomin Kang and Hongzhi Sun

peptide nullified the detrimental effects of PGRN on insulin action ( Liu et al . 2015 ). Although the emergence of PGRN as a regulator of energy metabolism, much less is known about the role of PGRN on chronic inflammation in AT. Sirtuin 1 (SIRT1) is an

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Jonathan Pham, Kanaga Arul Nambi Rajan, Ping Li and Mana M Parast

signaling pathways downstream of the nuclear receptor, PPARγ and the protein deacetylase, Sirt1, and how these pathways, individually and in combination, affect both the development and the function of the placenta. Figure 1 Cartoon of trophoblast

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Marta Correia-da-Silva, Verónica Rocha, Cláudia Marques, Cláudia M Deus, Adriana Marques-Carvalho, Paulo J Oliveira, Andreia Palmeira, Madalena Pinto, Emília Sousa, José Manuel Sousa Lobo and Isabel Filipa Almeida

supported by mechanistic data that indicates the involvement of increased expression and activation of the protein deacetylase sirtuin 1 (SIRT1) ( Baur & Sinclair 2006 , Price et al. 2012 ). Sirtuin 1 is expressed in skin keratinocytes ( Blander et al

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Ayse Basak Engin, Atilla Engin and Ipek Isik Gonul

resistance and hyperactivation of insulin-like growth factors (IGFs)-related pathways, the increased levels of aromatase activity, ER stress and excessive oxidative stress generation, uncoupled respiration and hypoxia, Sirtuin 1 (SIRT1) controversy ( Simone

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Keir Menzies and Johan Auwerx

contribute to accelerated aging ( Patti et al . 2003 , Joseph et al . 2012 ). The known and potential roles of sirtuin proteins in muscle energy homeostasis The sirtuin proteins (SIRT1–SIRT7) are a major subfamily of the KDACs. They have become

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Ashley A Able, Allison J Richard and Jacqueline M Stephens

sirtuin 1 (SIRT1), histone deacetylase 3 (HDAC3) and suppressor of variegation 3–9 homolog 1 (SUV39H1) ( Zhao et al. 2008 , Li et al. 2009 , Chini et al. 2010 ). SIRT1 is a NAD-dependent deacetylase involved in a variety of cellular processes

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Christopher E Wall, Ruth T Yu, Anne R Atkins, Michael Downes and Ronald M Evans

between PPARγ and the deacetylase sirtuin 1 (SIRT1). When deacetylated by SIRT1, PPARγ induces the expression of genes that mediate thermogenesis in white fat ( Qiang et al . 2012 ). Accordingly, a SIRT1 gain-of-function model resulted in a similar

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Fabio Malavasi, Silvia Deaglio, Gianluca Zaccarello, Alberto L Horenstein, Antonella Chillemi, Valentina Audrito, Sara Serra, Marina Gandione, Andrea Zitella and Alessandro Tizzani

, a non-selective cation channel whose prolonged activation leads to cell death ( Perraud et al . 2001 ). At least, seven sirtuins are described in mammalian cells. SIRT1, the most widely studied, deacetylates different histone and non

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Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Carlos Salomon and Martha Lappas

( Tran et al. 2017 ). Moreover, animal studies have shown that resveratrol has beneficial effects on maternal glucose metabolism and insulin sensitivity ( Roberts et al. 2014 ). Sirtuins In mammals, there are seven sirtuins (SIRT1-7) that