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Ilitch Aquino Marcondes-de-Castro, Thamiris Ferreira Oliveira, Renata Spezani, Thatiany Souza Marinho, Luiz Eduardo Macedo Cardoso, Marcia Barbosa Aguila, and Carlos Alberto Mandarim-de-Lacerda

Introduction The white adipose tissue (WAT) and liver are significant targets in obesity-associated diseases such as dyslipidemia, insulin resistance, and non-alcoholic fatty liver disease (NAFLD), beyond what obesity is directly associated

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Yajie Guo, Junjie Yu, Chunxia Wang, Kai Li, Bin Liu, Ying Du, Fei Xiao, Shanghai Chen, and Feifan Guo

Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide and is characterized by hepatic lipid accumulation in the absence of heavy alcohol consumption ( de Alwis & Day 2008 ). NAFLD is

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Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang, and Ming Dong

Introduction Non-alcoholic fatty liver disease (NAFLD) is known as a common liver disease in adults and children, which refers to a wide spectrum of liver damage from steatosis to non-alcoholic steatohepatitis, and cirrhosis ultimately. It is

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Bo Li, Zhiguo Zhang, Huizhi Zhang, Kai Quan, Yan Lu, Dongsheng Cai, and Guang Ning

Introduction Non-alcoholic fatty liver disease (NAFLD), characterised by excessive fat deposits in the liver, is a risk factor for a variety of metabolic diseases including obesity, dyslipidaemia and type 2 diabetes. It can also trigger a

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Xueyao Yin, Fenping Zheng, Qianqian Pan, Saifei Zhang, Dan Yu, Zhiye Xu, and Hong Li

Introduction Nonalcoholic fatty liver disease (NAFLD) consists of ectopic fat accumulation in the liver secondary to metabolic factors, mostly obesity and insulin resistance (IR) or diabetes mellitus ( Adams & Angulo 2005 ). The prevalence of NAFLD

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Gilberto Paz-Filho, Claudio Alberto Mastronardi, Brian J Parker, Ainy Khan, Antonio Inserra, Klaus I Matthaei, Monika Ehrhart-Bornstein, Stefan Bornstein, Ma-Li Wong, and Julio Licinio

-alcoholic fatty liver disease (NAFLD), the most common form of chronic liver dysfunction in developed countries. While NAFLD could be considered a component of the metabolic syndrome, the liver involvement includes a spectrum ranging from simple steatosis (NAFLD

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Haoyong Yu, Mingliang Zhang, Yunqin Ma, Junxi Lu, Jiemin Pan, Pan Pan, Haibing Chen, and Weiping Jia

Introduction NAFLD is the most common liver disease worldwide. It comprises a spectrum of disorders characterized by liver steatosis, with >5% of hepatocytes infiltrated by fat in individuals with no history of alcohol abuse or competing

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Tae Woo Jung, Hyoung-Chun Kim, Yong Kyoo Shin, Hyeyoung Min, Seong-Wan Cho, Zi Soo Kim, Su Mi Han, A M Abd El-Aty, Ahmet Hacımüftüoğlu, and Ji Hoon Jeong

An aqueous extract of Humulus japonicus (AH) has been documented to ameliorate hypertension and non-alcoholic fatty liver disease (NAFLD). Here, we investigated the effects of an aqueous extract of AH on thermogenesis and palmitate-induced oxidative stress in adipocytes. To verify the effect of AH on browning, we measured the expression levels of specific markers in 3T3-L1 adipocytes using qPCR and Western blotting, respectively. To assess the role of oxidative stress, cells were stained with DCFDA and observed by fluorescence microscopy. AH increased the expression of brown adipose tissue-specific markers. Additionally, it induced fatty acid oxidation and lipolysis and suppressed both lipogenic markers and lipid accumulation. Furthermore, AH ameliorated hydrogen peroxide-induced oxidative stress. Enhanced expression of these markers contributed to fat browning, fatty acid oxidation and lipolysis of 3T3-L1 adipocytes via the AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor delta (PPARδ) signaling pathways. Moreover, AMPK and PPARδ resulting in protective effects of AH against oxidative stress. In sum, AH could promote the browning, lipolysis and thermogenesis in 3T3-L1 adipocytes and would suppress the hydrogen peroxide-induced oxidative stress and lipogenesis during differentiation. We therefore suggest that AH could be used as a potential candidate for treating obesity and related metabolic disorders.

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Yi Wang, Qi-Ling Shen, Qi Xin, Bei Sun, Shi Zhang, Qian-Hua Fang, Ying-Xin Shi, Wen-Yan Niu, Jing-Na Lin, and Chun-Jun Li

Introduction Nonalcoholic fatty liver diseases (NAFLD) is becoming one of the most common causes of chronic liver disease due to the increasing incidence of obesity, type 2 diabetes (T2DM) and metabolic syndrome ( Tilg et al. 2017 ). The

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Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto, and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan

liver disease (NAFLD) and log-transformed plasma TG were assessed by logistic regression models and multiple regression analysis assuming an additive model of inheritance respectively. Age, sex, BMI, and a clinical history of diabetes were included in