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Kazutaka Nanba, Andrew X Chen, Adina F Turcu, and William E Rainey

adrenal steroid production results in various disorders. In vitro cell culture models provide important information for understanding molecular and cellular mechanisms controlling both the normal and pathologic function of the adrenal cortex. The H295R

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D Montanaro, M Maggiolini, A G Recchia, R Sirianni, S Aquila, L Barzon, F Fallo, S Andò, and V Pezzi

al. 2001 , Kirschner 2002 ). The H295R adrenocortical carcinoma cell line ( Rainey et al. 1994 ) was derived from H295 cells, which were established from a primary hormonally active adrenocortical carcinoma ( Gazdar et al. 1990 ), and

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Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, and Changlong Bi

retinopathy by regulating various pathogenetic pathways ( Yan et al. 2014 ). Notably, lncRNA H19 has been identified as an upstream modulator of gluconeogenesis and a regulator of hepatic glucose metabolism, and its lower hepatic level has been detected in

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Jin Bai, Thomas J Lechuga, Joshua Makhoul, Hao Yan, Carol Major, Afshan Hameed, and Dong-bao Chen

al. 2005 , Rosenfeld & Roy 2014 ), suggesting other mechanisms to mediate uterine hemodynamics. The proangiogenic vasodilator hydrogen sulfide (H 2 S) is endogenously produced mainly from l -cysteine by cystathionine β-synthase (CBS) and

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Qi Zhang, Qin Zhu, Ruyuan Deng, Feiye Zhou, Linlin Zhang, Shushu Wang, Kecheng Zhu, Xiao Wang, Libin Zhou, and Qing Su

-responsive element-binding protein H (CREBH), a liver-specific transcriptional factor. Knockdown of CREBH abolished MS-275-induced hepatic FGF21 expression, suggesting that MS-275 exerts its metabolic action via activating CREBH-induced FGF21 expression

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Sheng Y Ang, Bronwyn A Evans, Daniel P Poole, Romke Bron, Jesse J DiCello, Ross A D Bathgate, Martina Kocan, Dana S Hutchinson, and Roger J Summers

enteroendocrine L-cell model NCI-H716 cell line, and goblet-like colorectal cell lines LS513 and SW1463, endogenously express RXFP4 . Importantly, in NCI-H716 cells, INSL5 stimulates signalling and regulates GLP-1 secretion, suggesting a potential novel

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Isabel Moscoso, María Cebro-Márquez, Moisés Rodríguez-Mañero, José Ramón González-Juanatey, and Ricardo Lage

Cell culture and reagents H9c2 cells were obtained from ATCC. H9c2 cells were chosen because these cells maintain electrical and hormonal signal pathway elements of adult cardiac cells ( Hescheler et al. 1991 ), in addition to sensitivity to hypoxia

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Joong Kwan Kim, Yongchul Lim, Jung Ok Lee, Young-Sun Lee, Nam Hee Won, Hyun Kim, and Hyeon Soo Kim

-terminal tails of histone H3, Arg2, Arg17, and Arg26 ( Schurter et al . 2001 ). Two groups have reported that asymmetric dimethylation of Arg2 in histone H3 was mainly catalyzed by PRMT6 ( Guccione et al . 2007 , Iberg et al . 2008 ). Chromatin

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J Liu, X-D Li, A Ora, P Heikkilä, A Vaheri, and R Voutilainen

proliferation and apoptosis. Materials and methods Cell cultures Human adrenocortical carcinoma cell line NCI-H295R (H295R) from the American Type Culture Collection (ATCC; Rockville, MD, USA) was grown in a 1:1 mixture

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Rune Ehrenreich Kuhre, Nicolai Jacob Wewer Albrechtsen, Carolyn Fiona Deacon, Emilie Balk-Møller, Jens Frederik Rehfeld, Frank Reimann, Fiona Mary Gribble, and Jens Juul Holst

-cell, or for dissecting the underlying molecular mechanisms coupling stimulus to secretion. Therefore, it was not until the development of three GLP-1-producing cell lines, namely GLUTag, STC-1, and NCI-H716, in the 1990s that the specific molecular