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Weiye Zhao Department of Biology, University of York, York, UK

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Susanna F Rose Department of Biology, University of York, York, UK

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Ryan Blake CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Aňze Godicelj Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Smith Building, Boston, Massachusetts, USA

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Amy E Cullen CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Jack Stenning Department of Biology, University of York, York, UK

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Lucy Beevors The Institute of Metabolism and Systems Research (IMSR), University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK

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Marcel Gehrung CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Sanjeev Kumar Chris O’Brien Lifehouse, Sydney, New South Wales, Australia

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Kamal Kishore CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Ashley Sawle CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Matthew Eldridge CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Federico M Giorgi Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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Katherine S Bridge Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK

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Florian Markowetz CRUK Cambridge Institute, University of Cambridge, Cambridge, UK

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Andrew N Holding Department of Biology, University of York, York, UK
York Biomedical Research Institute, University of York, York, UK
The Alan Turing Institute, Kings Cross, London, UK

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( Glont et al. 2019 ). Five micrograms anti-ZMIZ1 antibody (Abnova, PAB4820) or normal rabbit IgG (Cell Signaling Technology, 2729) was used for each ChIP reaction. The following primers were used for probing the promoter of E2F2 (forward 5

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-23-0133
Volume/Issue:
Volume 73: Issue 1
Open access
Amanda M Ackermann Departments of Medicine,
Molecular Physiology and Biophysics and
Program in Developmental Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue 746 PRB, Nashville, Tennessee 37232, USA

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Maureen Gannon Departments of Medicine,
Molecular Physiology and Biophysics and
Program in Developmental Biology, Vanderbilt University Medical Center, 2220 Pierce Avenue 746 PRB, Nashville, Tennessee 37232, USA

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. (2004) Rip-dnCREB Tg ↓ β cell mass, ↑ β cell apoptosis Jhala et al. (2003)     E2Fs E2F1 −/− ↓ β cell mass, ↓ β cell proliferation, ↔β cell apoptosis Fajas et al. (2004) E2F1 −/− ;E2F2 −/− ↓ β cell mass, ↑ β cell proliferation Iglesias et al. (2004

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JME-06-0053
Volume/Issue:
Volume 38: Issue 2
Free access
Angela M Davis Animal Sciences, Departments of
Animal Sciences, Departments of

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Jiude Mao Animal Sciences, Departments of

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Bushra Naz Animal Sciences, Departments of

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Jessica A Kohl Animal Sciences, Departments of

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Cheryl S Rosenfeld Animal Sciences, Departments of

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-associated transcription factors ( E2f2 , Ets1 , Etv5 , Hdac4 , and Nr4a2 ). A few pro-apoptotic ( E2f3 and Dapk1 ) and anti-apoptotic ( Api5 , Syvn1 , and Nfatc2ip ) genes were also down-regulated by the high dose of 17β-estradiol. While the individual SERM

Article Type:
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DOI:
https://doi.org/10.1677/JME-08-0029
Volume/Issue:
Volume 41: Issue 4
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Andreas Petri
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Jonas Ahnfelt-Rønne
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Klaus Stensgaard Frederiksen
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David George Edwards
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Dennis Madsen
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Palle Serup
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Jan Fleckner
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R Scott Heller
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e13 and e15 are at different developmental stages. At e13, a large group of apoptosis-related genes are identified ( Rnf130 , Gadd45g , Cdkn1a , Btg2 , Txnl1 , Sphk1 , 1700020C11Rik , Smndc1 , Pim2 , Unc5a and E2f2 ). While cell death has

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02096
Volume/Issue:
Volume 37: Issue 2
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Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Akira Yokomizo Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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Seiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

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). E2F/Rb The E2F family of transcription factors consists of nine members, all of which bind to the E2F-binding site (5′-TTTCGCGC-3′) in the target promoter sequence. Three of them are activators: E2F-1, E2F-2, and E2F-3a, while the remaining six, E2F

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0018
Volume/Issue:
Volume 47: Issue 1
Free access