Introduction Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are ligand-dependent transcription receptors of the subfamily 1 (NR1) in the nuclear receptor superfamily. The NR1 group also includes retinoic acid
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Kwang-Huei Lin, Chia-yu Chen, Shen-Liang Chen, Chun-Che Yen, Ya-Hui Huang, Chung-hsuan Shih, Jiann-Jong Shen, Rong-Chi Yang, and Chia-Siu Wang
thyroid hormone nuclear receptor with antibody: characterization of the thyroid hormone binding site. Biochemical and Biophysical Research Communications 210 464 –471. Borsi L , Castellani P, Risso AM, Leprini A & Zardi L
Alok Mishra, Xu-guang Zhu, Kai Ge, and Sheue-Yann Cheng
genomic actions of T 3 are mediated by thyroid hormone nuclear receptors (TRs). There are two TR genes, TRα and TRβ , located on different chromosomes, to encode three major T 3 binding receptors, α1, β1, and β2 ( Cheng 2000 ). These TR isoforms
Anne Wulf, Marianne G Wetzel, Maxim Kebenko, Meike Kröger, Angelika Harneit, Jennifer Merz, and Joachim M Weitzel
-regulated genes, unliganded TR suppresses basal gene transcriptional activity by interacting with corepressors such as nuclear receptor corepressor (NCoR) and by silencing mediator of retinoid and thyroid hormone receptors (SMRT). Corepressors are associated
Xu-guang Zhu, Dong Wook Kim, Michael L Goodson, Martin L Privalsky, and Sheue-Yann Cheng
in hyperthyroidism reduces plasma low-density lipoprotein cholesterol, lipoproteins, and triglycerides and leads to weight loss. T 3 acts via binding to thyroid hormone receptors (TRs), which are members of the nuclear receptor superfamily. TRs are
Cecilia Verga Falzacappa, Eleonora Petrucci, Valentina Patriarca, Simona Michienzi, Antonio Stigliano, Ercole Brunetti, Vincenzo Toscano, and Silvia Misiti
Introduction Thyroid hormone, T 3 , is classically known for its ability to regulate gene expression via binding with thyroid hormone receptors (TRs) on specific promoter regions of target genes. TRs act as ligand
Marie-Belle Poirier, Liette Laflamme, and Marie-France Langlois
. Thyroid hormone receptors (TR) are very well conserved members of the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. The transcriptional regulation of TH target genes is mediated via the binding of TRs to thyroid hormone
K J Oliveira, T M Ortiga-Carvalho, A Cabanelas, M A L C Veiga, K Aoki, H Ohki-Hamazaki, K Wada, E Wada, and C C Pazos-Moura
. Schomburg L & Bauer K 1995 Thyroid hormones rapidly and stringently regulate the messenger RNA levels of the thyrotropin-releasing hormone (TRH) receptor and the TRH-degrading ectoenzyme. Endocrinology 136 3480 –3485
Maria D'Agostino, Marialuisa Sponziello, Cinzia Puppin, Marilena Celano, Valentina Maggisano, Federica Baldan, Marco Biffoni, Stefania Bulotta, Cosimo Durante, Sebastiano Filetti, Giuseppe Damante, and Diego Russo
requires adequate tumor tissue expression of genes that play key roles in iodine metabolism, in particular those encoding the thyroid-stimulating hormone receptor (TSHR) and the sodium/iodide symporter (NIS) ( Schlumberger et al . 2007 , Wartofsky & Van
Ricardo Núñez Miguel, Jane Sanders, Paul Sanders, Stuart Young, Jill Clark, Katarzyna Kabelis, Jane Wilmot, Michele Evans, Emma Roberts, Xiaoling Hu, Jadwiga Furmaniak, and Bernard Rees Smith
Konno R Furmaniak J Rees Smith B 1999 Measurement of thyroid-stimulating hormone receptor autoantibodies by ELISA . Clinical Chemistry 45 2285 – 2287 . Chen C-R McLachlan SM Rapoport B 2010 Thyrotropin (TSH) receptor residue E251
