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Marta Santos-Hernández Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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Frank Reimann Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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Fiona M Gribble Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

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information about dietary nutrients entering the bloodstream. The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) play a particularly important role in glucose metabolism and regulation of food intake

Article Type:
Review Article
Collections:
Incretins
DOI:
https://doi.org/10.1530/JME-23-0112
Volume/Issue:
Volume 72: Issue 4
Open access
Custodia García-Jiménez
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Jose Manuel García-Martínez
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Ana Chocarro-Calvo
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Antonio De la Vieja Departamento de Fisiología y Bioquímica, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Madrid, Spain

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with diabetes has remained elusive, but since their discovery, WNT/β-catenin signaling has been shown to increase the expression of incretin hormones ( Garcia-Martinez et al . 2009 ) that are global regulators of metabolism and are required for normal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0152
Volume/Issue:
Volume 52: Issue 1
Free access
Erik Elebring Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Anna Casselbrant Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Sara M T Persson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Lars Fändriks Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden

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Ville Wallenius Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden

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already in the gastrointestinal tract ( Lu et al. 2021 ). Nutrients, like carbohydrates and fat, can stimulate hormone secretion from enteroendocrine cells (EECs) residing in the epithelial layer of the gut. Incretins are hormones secreted from EECs in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0115
Volume/Issue:
Volume 70: Issue 4
Open access
Hongjie Zhang State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China
State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Jing Li State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Xiangying Liang State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Yun Luo State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Ke Zen State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Chen-Yu Zhang State Key Laboratory of Pharmaceutical Biotechnology, First Affiliated Hospital of Nanjing Medical University, School of Biological Sciences, Jiangsu Diabetes Center, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China

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Introduction It is widely recognized that oral ingestion of glucose triggers more insulin release than intravenous delivery of glucose, which results in a similar plasma glucose profile – a phenomenon known as the ‘incretin effect’ ( Elrick et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0114
Volume/Issue:
Volume 48: Issue 2
Free access
Sufang Chen Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA
Department of Geriatric Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

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Wei Wei Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA
Department of Bile Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Minjie Chen Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Xiaobo Qin Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Lianglin Qiu Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA
Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong, China

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Li Zhang Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Yuhao Zhang Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China

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Qi Cao Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Zhekang Ying Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland, USA

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resistance, it may also impact glucose metabolism through effects on insulin secretion. Glucagon-like peptide-1 (GLP-1) is one of the primary incretins that is primarily produced by intestinal enteroendocrine L-cells ( Drucker 2018 ). It may enhance insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0129
Volume/Issue:
Volume 61: Issue 4
Free access
Jong-Ik Hwang Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Seongsik Yun Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Mi Jin Moon Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Cho Rong Park Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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Jae Young Seong Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea

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hypoglycemia under normal plasma glucose concentration conditions ( Baggio & Drucker 2002 , Nauck et al . 2002 ). In addition to its incretin activity, GLP1 stimulates proliferation and differentiation of pancreatic β-cells ( Xu et al . 1999 , Drucker 2003

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0137
Volume/Issue:
Volume 52: Issue 3
Free access
Hamedeh Ghanaat-Pour Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Zhen Huang Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Mikael Lehtihet Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Åke Sjöholm Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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(GIPr; NM_012714) was approximately twofold lower in GK low glucose when compared with GK high glucose. This suggests a tonic reduction of incretin signaling in GK islets, potentially a major contributor to the islet defect in this diabetes model. Since

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-07-0002
Volume/Issue:
Volume 39: Issue 2
Free access
Weijuan Shao Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Vivian Szeto Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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Zhuolun Song Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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Lili Tian Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Zhong-Ping Feng Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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M Cristina Nostro Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada

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Tianru Jin Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Center, University of Toronto, Toronto, Ontario, Canada

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collectively confirmed the existence of the TCF7L2–ISL1 transcriptional network in rodent islets. More importantly, our investigations have expanded this novel network study into the function of the incretin hormone GLP-1, on which a series of diabetes drugs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0181
Volume/Issue:
Volume 61: Issue 1
Free access
Quinn Dufurrena Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA

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Nils Bäck Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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Richard Mains Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA

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Louis Hodgson Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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Herbert Tanowitz Departments of Pathology, Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

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Prashant Mandela School of Pharmacy, University of Saint Joseph, Hartford, Connecticut, USA

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Betty Eipper Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut, USA

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Regina Kuliawat Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

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-like peptide 1 (GLP-1), an incretin which also activates Rac1 ( Kalwat & Thurmond 2013 ), we show that Kalirin more specifically integrates glucose signaling and granule age-related secretory decisions. Materials and methods Materials Monoclonal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0048
Volume/Issue:
Volume 62: Issue 1
Free access
Yuki Aida Laboratory of Molecular Medical Bioscience, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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Kohsuke Kataoka Laboratory of Molecular Medical Bioscience, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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of mRNA stability ( Wang et al. 2020 ). At the transcriptional level, MafA mRNA is downregulated by low glucose as well as chronic high glucose ( Kataoka et al. 2002 , Wang et al. 2007 ). On the other hand, incretin hormones upregulate MafA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-24-0023
Volume/Issue:
Volume 73: Issue 3
Restricted access