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Marie Berenguer Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

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Gregg Duester Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

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, Tickle et al. 1982 ), suggesting that RA may be important for limb development. A major breakthrough in how RA controls development occurred upon discovery of nuclear RA receptors (RARs), which use RA as a ligand to control transcription of key genes

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0041
Volume/Issue:
Volume 69: Issue 4
Free access
Vincent Giguère Goodman Cancer Institute, McGill University, Montréal, Quebec, Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada

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Ronald M Evans The Salk Institute for Biological Studies, La Jolla, California, USA

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history of vitamin A and of the unanticipated discovery that its receptor would be a member of the nuclear receptor family now referred to as the retinoic acid receptor (RAR) ( Giguère et al. 1987 ). A companion article in this commemorative issue

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0117
Volume/Issue:
Volume 69: Issue 4
Free access
Martin Petkovich Department of Pathology and Molecular Medicine, Queens University, Kingston, Ontario, Canada

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Pierre Chambon Institut de Génétique et de Biologie Moléculaire et Cellulaire (I.G.B.M.C.), Illkirch, France

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and chemical libraries. The results of our DNA-binding domain swap between the receptors which became known as the retinoic acid receptor (RAR) and the ER resolved the transcriptional activity question spectacularly well. They clearly demonstrated

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0097
Volume/Issue:
Volume 69: Issue 4
Free access
Fraydoon Rastinejad Nuffield Department of Medicine, University of Oxford, Target Discovery Institute (NDM RB), Oxford, UK

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Introduction The retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are the earliest and most intensely studied nuclear receptors (NRs) for their three-dimensional (3D) structures. Both receptor groups bind to retinoic acids (RAs

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0113
Volume/Issue:
Volume 69: Issue 4
Open access
Jessica A Deis Department of Food Science and Nutrition, University of Minnesota, Twin Cities, Minnesota, USA

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Hong Guo Department of Food Science and Nutrition, University of Minnesota, Twin Cities, Minnesota, USA

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Yingjie Wu Institute for Genomic Engineered Animal Models of Human Diseases, Dalian Medical University, Dalian, China

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Chengyu Liu Transgenic Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

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David A Bernlohr Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Twin Cities, Minnesota, USA

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Xiaoli Chen Department of Food Science and Nutrition, University of Minnesota, Twin Cities, Minnesota, USA

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brown-like morphology of WAT adipocytes ( Alvarez et al . 1995 , Kumar et al . 1999 , Mercader et al . 2006 ). RA is known to exert its effect on thermogenesis through binding and nuclear translocation of the retinoic acid receptor-alpha (RAR

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0017
Volume/Issue:
Volume 61: Issue 3
Free access
Y.-J. Y. Wan
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L. Wang
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T.-C. J. Wu
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ABSTRACT

The presence of retinoic acid receptor (RAR) α, β and γ mRNA was examined in 16 different kinds of rat tissue using the highly sensitive reverse transcriptase-polymerase chain reaction technique. The data demonstrated that each tissue expressed at least two types of RAR mRNA. Among the three types of RAR mRNA, RAR α was widely expressed in all types of organ and was the dominant form expressed in the gastrointestinal tract. RAR β mRNA was not present in the intestine and spleen. In addition, RAR β mRNA levels were high in the heart, lung, brain, testis and epididymis. RAR γ mRNA was abundant in both male and female reproductive systems, as well as epidermal tissues. The prevalence of each RAR mRNA in the tissues suggests the diverse biological roles of these receptors.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.0.0090291
Volume/Issue:
Volume 9: Issue 3
Restricted access
Marcel J M Schaaf Institute of Biology (IBL), Leiden University, Leiden, The Netherlands

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one-third of zebrafish NR articles deals with the NR1 family of receptors (241), with RAR (63) and PPAR (50) being the most popular subjects to study. No publications were listed on NOR1 and EAR-2 in zebrafish. In this review, research will be

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0031
Volume/Issue:
Volume 59: Issue 1
Free access
Russell Snyder Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 1300 South Coulter, Amarillo, Texas 79106, USA

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Thomas Thekkumkara Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 1300 South Coulter, Amarillo, Texas 79106, USA

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metabolite of preformed vitamin A, exerts its function by binding to nuclear receptors (RXR and RAR) and forming complexes with specific sequences on promoter regions of target genes called retinoic acid response elements ( Mark et al . 2006 ). Therefore

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-11-0095
Volume/Issue:
Volume 48: Issue 2
Free access
C Féart Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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J Vallortigara Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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D Higueret Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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B Gatta Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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A Tabarin Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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V Enderlin Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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P Higueret Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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V Pallet Unité de Nutrition et Signalisation Cellulaire (E.A. MENRT, Usc INRA) ISTAB, Avenue des Facultés Université Bordeaux 1, 33405 Talence, France
Service de Biochimie de l’Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, 33000 Bordeaux, France
Service d’Endocrinologie, Diabétologie et Maladies Métaboliques de l’Hôpital Haut-Levêque, Centre Hospitalier Universitaire de Bordeaux, Avenue Magellan, 33600 Pessac, France

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, reviewed by Bastien & Rochette-Egly 2004 ). It has been shown that RXR forms heterodimers with either RAR or TR in order to regulate gene transcription by interacting with distinct sequences in the promoter of target genes. The fact that RXR is the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01662
Volume/Issue:
Volume 34: Issue 3
Free access
Angela Nebbioso Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Carmela Dell'Aversana Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Anne Bugge Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Roberta Sarno Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Sergio Valente Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Dante Rotili Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Fabio Manzo Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Diana Teti Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Susanne Mandrup Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Paolo Ciana Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Adriana Maggi Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Antonello Mai Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Hinrich Gronemeyer Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Lucia Altucci Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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effects of class II HDACs in two different NR-dependent differentiation systems, we show that the class II-specific inhibitor MC1568 interferes with the transcriptional signaling of RARs as well as PPARγ. That we are able to interfere with retinoic acid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0043
Volume/Issue:
Volume 45: Issue 4
Free access