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Stefania Carobbio Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Barry Rosen Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Antonio Vidal-Puig Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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cellular models based on hES and IPS cell technology for BAT differentiation/activation to be used in functional studies, -omics based analyses and validation of therapeutic approaches. A matter of adipocyte colours: brown, white, and beige/brite Until

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-13-0158
Volume/Issue:
Volume 51: Issue 3
Free access
Indrajit Chowdhury Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia, USA
Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia, USA

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Kelwyn Thomas Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia, USA

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Anthony Zeleznik Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Winston E Thompson Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia, USA
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia, USA

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Introduction Mammalian granulosa cells (GCs) are multilayered somatic cells residing within the ovarian follicle that support oogenesis through proliferation, differentiation, and interactive communications. These events are under the control

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0278
Volume/Issue:
Volume 56: Issue 4
Open access
Hanwei Cui Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

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Qian Yi Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

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Jianguo Feng Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

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Li Yang Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

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Liling Tang Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

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splicing of exons 5 gives rise to a unique E domain of MGF (MGF E peptide) ( Dai et al . 2010 ). It is reported that MGF E peptide activated myoblasts C2C12 and myocardial cells H9C2 proliferation, while delaying the differentiation of C2C12 ( Yang

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0157
Volume/Issue:
Volume 52: Issue 2
Free access
Yali Ling National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Feng Xu National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Xuedi Xia National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Dexing Dai National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Ruoman Sun National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhongjian Xie National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), anaplastic thyroid carcinoma (ATC), and medullary thyroid carcinoma. FTC and PTC are also defined as differentiated thyroid carcinoma (DTC), accounting for 90% of thyroid malignancies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0167
Volume/Issue:
Volume 68: Issue 3
Open access
Jin Hong Chen Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea

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Chen Shen Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea

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Ha Ram Oh Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea

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Ji Hyun Park Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea

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stem cells ( Chew et al. 2005 ). The expression of these pluripotency genes gradually decreases during cell differentiation ( Miyamoto et al. 2015 ). Mature osteoblasts are the primary component in the bone formation process, which includes matrix

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-21-0213
Volume/Issue:
Volume 68: Issue 4
Restricted access
Lorraine J Gudas Department of Pharmacology, and Revlon Pharmaceutical Professor of Pharmacology and Toxicology, Pharmacology Department, Weill Cornell Medicine of Cornell University, and the Meyer Cancer Center of Weill Cornell Medicine, New York, New York, USA

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allow for the proper levels of biologically active retinoids to be achieved in specific cell types in the body. Since RA regulates stem cell differentiation and is active at nanomolar concentrations in cells, levels of this signaling molecule must be

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-22-0082
Volume/Issue:
Volume 69: Issue 4
Free access
Andrei S Chagin
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Henry M Kronenberg Department of Physiology and Pharmacology, Endocrine Unit, Karolinska Institutet, Nanna Svartz Vagen 2, Stockholm 17177, Sweden

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with condensation of mesenchymal cells with their subsequent differentiation into chondrocytes ( Hall & Miyake 1995 ). The chondrocytes proliferate thereby increasing the size of the primary skeletal element. The cells in the center of the element stop

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-14-0093
Volume/Issue:
Volume 53: Issue 2
Free access
Junye Chen Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Nanchang Joint Programme, Queen Mary, University of London, London, UK

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Yi Lu Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China

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Mengyuan Tian Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Nanchang Joint Programme, Queen Mary, University of London, London, UK

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Qiren Huang Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China
Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China

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FOXO1, FOXO3, FOXO4 and FOXO6 ( Ogg et al. 1997 , Tzivion et al. 2011 ). FOXO1 is one of the downstream targets of AKT ( Fig. 1 ) and takes part in cell cycle control, apoptosis, metabolism and adipocyte differentiation ( Dowell et al. 2003

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0178
Volume/Issue:
Volume 62: Issue 3
Free access
Angela Nebbioso Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Carmela Dell'Aversana Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Anne Bugge Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Roberta Sarno Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Sergio Valente Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Dante Rotili Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Fabio Manzo Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Diana Teti Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Susanne Mandrup Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Paolo Ciana Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Adriana Maggi Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Antonello Mai Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Hinrich Gronemeyer Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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Lucia Altucci Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy
Dipartimento di Patologia Generale, Dipartimento di Patologia e Microbiologia Sperimentale, University of Southern Denmark, Dipartimento di Studi Farmaceutici, Department of Cancer Biology, Università degli Studi di Milano, CNR-IGB, Seconda Università di Napoli, 80138 Napoli, Italy

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the regulation of differentiation, such as myogenesis ( Lu et al . 2000 ), neuronal differentiation ( Chawla et al . 2003 ), and osteogenesis ( Hug 2004 ). Mechanistically, class IIa members may compete with the histone acetyltransferase p300 for

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0043
Volume/Issue:
Volume 45: Issue 4
Free access
Diana Vargas Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Noriaki Shimokawa Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Ryosuke Kaneko Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Wendy Rosales Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Adriana Parra Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Ángela Castellanos Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Noriyuki Koibuchi Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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Fernando Lizcano Center of Biomedical Research (CIBUS), Department of Integrative Physiology, Institute of Experimental Animal Research, Universidad de La Sabana, Km. 7 Autopista Norte de Bogota, 140013 Chia, Colombia

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represents an interesting challenge ( Cypess et al . 2009 , Vitali et al . 2012 , Berry & Rodeheffer 2013 , Lidell et al . 2014 ). The differentiation of beige adipocytes from precursor cells and WAT beiging transdifferentiation from white adipocytes is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0148
Volume/Issue:
Volume 56: Issue 2
Free access