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Changxue Lu and Sheue-Yann Cheng

H-mutated TRα1 manifest visceral obesity, hyperleptinemia, reduced catecholamine-stimulated lipolysis in WAT, and hepatic steatosis ( Liu et al . 2007 ). In the absence of T 3 , wild-type TRα1 and P398H mutant significantly reduce PPARα

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Bo Zhou, Huixia Li, Jiali Liu, Lin Xu, Qinyue Guo, Hongzhi Sun, and Shufang Wu

476 – 491 . ( doi:10.1016/j.cell.2007.08.047 ). Stralfors P Honnor RC 1989 Insulin-induced dephosphorylation of hormone-sensitive lipase: correlation with lipolysis and cAMP-dependent protein kinase activity . European Journal of Biochemistry

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Ana Luísa Neves, João Coelho, Luciana Couto, Adelino Leite-Moreira, and Roberto Roncon-Albuquerque Jr

of triglyceride, hepatic de novo fatty acid synthesis, and lipolysis. High doses of LPS produce hypertriglyceridemia by decreasing lipoprotein catabolism. Administration of TNF antibodies or IL1 receptor antagonist did not prevent the increase in

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Eva Tudurí, Monica Imbernon, Rene Javier Hernández-Bautista, Marta Tojo, Johan Fernø, Carlos Diéguez, and Rubén Nogueiras

-Hyiaman et al . 2008 ). In addition, activation of CB1 increases lipogenesis and inflammation and reduces lipolysis, in the white adipose tissue (WAT) ( Silvestri & Di Marzo 2013 ). Furthermore, CB1 activation impairs insulin sensitivity, as evidenced by

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Subhamoy Dasgupta and Bert W O'Malley

protected from high-fat diet-induced obesity and exhibit increased insulin sensitivity, higher lipolysis, and reduced fat uptake ( Picard et al . 2002 ). Loss of Src-2 −/− also affects the hepatic glucose release due to decreased expression of glucose-6

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Carolina Gustavsson, Tomoyoshi Soga, Erik Wahlström, Mattias Vesterlund, Alireza Azimi, Gunnar Norstedt, and Petra Tollet-Egnell

. 2005 ) and antioxidant ( Louet et al . 2004 , Baba et al . 2005 , Borrás et al . 2005 ) properties. Oestrogens have also been shown to inhibit lipogenesis and stimulate lipolysis in abdominal visceral fat depots, to promote use of lipid as a fuel

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J H Duncan Bassett and Graham R Williams

hormone receptors . Bone 36 607 – 616 . Liu YY Schultz JJ Brent GA 2003 A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice . Journal of

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Afreen Idris Shariff, Sohail Syed, Rebecca A Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio, and Leonor Corsino

adipose tissue, CST increases the breakdown of lipids by inducing lipolysis and raising local accumulation of non-sterified fatty acids, a mechanism that has been associated with greater increasing insulin resistance ( Perez et al. 2014 ). Apart from

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Johan Svensson, Sofia Movérare-Skrtic, Sara Windahl, Charlotte Swanson, and Klara Sjögren

some or all of the lipolysis that is independent of hormone-sensitive lipase ( Soni et al . 2004 ), was up-regulated in muscle by E 2 , indicating increased utilization of free fatty acids as fuel. Synaptic transmission DHT up-regulated several genes

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Davids Fridmanis, Ramona Petrovska, Dace Pjanova, Helgi B Schiöth, and Janis Klovins

, Kovalitskaia et al . 2008 ). In the adrenal cortex, MC2R affects glucocorticoid production ( Clark & Cammas 1996 ) and synthesis of its own mRNA ( Naville et al . 1999 ). Research with mouse adipocytes has shown that MC2R participates in lipolysis ( Boston