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Edwin J W Geven, Folkert Verkaar, Gert Flik and Peter H M Klaren

, Schreck 2000 ). Cortisol stimulates gluconeogenesis and lipolysis ( Sheridan 1988 , van der Boon et al. 1991 ), which result in increased plasma glucose and free fatty acid levels. These catabolic actions of cortisol reflect its glucocorticoid potency

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Jin-Seung Choung, Young-Sun Lee and Hee-Sook Jun

lipolysis and free fatty acid utilization, contributing to the activation of UCP-1. β 3 -adrenergic receptors are thought to play a role in thermogenesis in brown fat and skeletal muscle, induce adaptive non-shivering thermogenesis and stimulate UCP1

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Changxue Lu and Sheue-Yann Cheng

H-mutated TRα1 manifest visceral obesity, hyperleptinemia, reduced catecholamine-stimulated lipolysis in WAT, and hepatic steatosis ( Liu et al . 2007 ). In the absence of T 3 , wild-type TRα1 and P398H mutant significantly reduce PPARα

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J H Duncan Bassett and Graham R Williams

hormone receptors . Bone 36 607 – 616 . Liu YY Schultz JJ Brent GA 2003 A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice . Journal of

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Ting Qi, Yanming Chen, Honggui Li, Ya Pei, Shih-Lung Woo, Xin Guo, Jiajia Zhao, Xiaoxian Qian, Joseph Awika, Yuqing Huo and Chaodong Wu

and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue . Cell Signal 28 1401 – 1411 . ( doi:10.1016/j.cellsig.2016.06.018 ) Zheng J Woo S-L Hu X Botchlett R

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Kazuyoshi Ukena, Tomohiro Osugi, Jérôme Leprince, Hubert Vaudry and Kazuyoshi Tsutsui

-induced lipolysis ( Malumba et al . 2010 ). As 3T3-L1 cells express the QRFPR-encoding gene, it appears that 26RFa/QRFP may act in an autocrine/paracrine manner to regulate adipogenesis ( Malumba et al . 2010 ). According to Alonzeau et al . (2013) , 26RFa

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Davids Fridmanis, Ramona Petrovska, Dace Pjanova, Helgi B Schiöth and Janis Klovins

, Kovalitskaia et al . 2008 ). In the adrenal cortex, MC2R affects glucocorticoid production ( Clark & Cammas 1996 ) and synthesis of its own mRNA ( Naville et al . 1999 ). Research with mouse adipocytes has shown that MC2R participates in lipolysis ( Boston

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Carolina Gustavsson, Tomoyoshi Soga, Erik Wahlström, Mattias Vesterlund, Alireza Azimi, Gunnar Norstedt and Petra Tollet-Egnell

. 2005 ) and antioxidant ( Louet et al . 2004 , Baba et al . 2005 , Borrás et al . 2005 ) properties. Oestrogens have also been shown to inhibit lipogenesis and stimulate lipolysis in abdominal visceral fat depots, to promote use of lipid as a fuel

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Subhamoy Dasgupta and Bert W O'Malley

protected from high-fat diet-induced obesity and exhibit increased insulin sensitivity, higher lipolysis, and reduced fat uptake ( Picard et al . 2002 ). Loss of Src-2 −/− also affects the hepatic glucose release due to decreased expression of glucose-6

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Elisa Manieri and Guadalupe Sabio

secretion of adipokines ( Gavrilova et al . 2000 ). In the obese state, adipocyte enlargement induces molecular and cellular alterations that affect whole-body metabolic homeostasis. Increased lipolysis in adipocytes leads to increased hyperlipidaemia and