Search Results

You are looking at 81 - 90 of 268 items for :

Clear All
Free access

Ronald M Evans

prostate, breast and ovarian cancer. Jan-Ake Gustafsson reviews for us the complex biology and mechanism of ER action throughout the body and focuses on the divergent roles of these two closely related receptors ( Dey et al . 2013 ). ERα is an established

Free access

Xiaohui Wang, Yidong Li, Xiaoyan Zhu, Yan Wang, Fei Diao and Jian Lu

, Nightingale et al . 2003 , Litvinov et al . 2004 ). For example, the growth of prostate cancer cell lines lacking androgen receptor (e.g. PC-3 cells) was faster than that of cells expressing androgen receptors (e.g. LNCap cells) ( Chlenski et al . 2001

Free access

Afreen Idris Shariff, Sohail Syed, Rebecca A Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio and Leonor Corsino

Prostate cancer T2DM 1. Hyperinsulinemia 2. Change in body fat composition Not known Tyrosine kinase inhibitors (TKI) and their relation to diabetes Tyrosine kinase activation of the intracellular β domain of the insulin receptor is a

Free access

Ryan J O Dowling, Saroj Niraula, Vuk Stambolic and Pamela J Goodwin

SU Breast HR (relative to metformin users) Currie et al . (2009) B 0.98 (0.69–1.41) Colorectal C 1.80 (1.29–2.53) Pancreas P 4.95 (2.74–8.96) Prostate R 1.07 (0.76–1.49) Metformin+SU B 0.90 (0.67–1.21) C 1.43 (1.05–1.94) P 0.38 (0.13–1.12) R 1.18 (0

Free access

T Ichikawa, K Horie-Inoue, K Ikeda, B Blumberg and S Inoue

. 1997 ) or placental bone morphogenetic protein ( Hromas et al. 1997 ), and also later named prostate-derived factor ( Paralkar et al. 1998 ) or non-steroidal anti-inflammatory drug-activated gene ( Baek et al. 2001 ). GDF15 is abundantly expressed

Free access

Subhamoy Dasgupta and Bert W O'Malley

such as breast, prostate, ovarian, and endometrial cancers ( Lonard & O'Malley 2012 ) and their functions in other types of cancer are rapidly being decoded ( Fig. 3 ). SRC-1 and SRC-3 promote ER-dependent breast cancer proliferation, as well as

Free access

Russell A Prough, Barbara J Clark and Carolyn M Klinge

intestine, colon, spleen, prostate, and testis. This pathway is reviewed in Labrie et al . 2001 ; Labrie et al . 2005 ; Labrie 2015a , b . Prepubertal elevations in serum DHEA/DHEA-S are coincident with the differentiation of the adrenal zona

Free access

Nelson D Horseman and Karen A Gregerson

reported. An interesting in vivo experiment has been recently reported, in which expression of Δ1-9-G129R-hPRL inhibited prostate tumors that were induced by overexpression of PRL ( Rouet et al . 2010 ). The study is limited by its obvious tautology in

Free access

Nektarios Barabutis, Agnieszka Siejka, Andrew V Schally, Norman L Block, Renzhi Cai and Joseph L Varga

(Manassas, VA, USA) and cultured at 37 °C in a humidified 95% air/5% CO 2 atmosphere. These cells lines were cultured in DMEM supplemented with antibiotics/antimycotics and 10% FBS. Benign prostate hyperplasia cells (BPH-1) were kindly donated by Dr Simon

Free access

L A Bach

IGFBPs inhibit tumorigenesis, it appeared that IGFBP-2 predominantly promotes this process ( Russo et al . 2015 ). Circulating IGFBP-2 levels correlated with established tumor markers and aggressiveness in many cancers including prostate, breast and