Search Results

You are looking at 81 - 90 of 464 items for :

Clear All
Free access

I J Bujalska, M Quinkler, J W Tomlinson, C T Montague, D M Smith and P M Stewart

Introduction The magnitude and severity of the obesity epidemic ( Kopelman 2000 ) have provided the impetus to further understand its genetic basis as well as focussing attention on the neuroendocrine regulation of appetite control

Free access

Abby F Fleisch, Robert O Wright and Andrea A Baccarelli

first proposed by Waddington (1942) . One of the more intriguing facets of epigenetics is the responsiveness of many epigenetic marks to environmental factors. The hereditary component of complex, multifactorial processes such as obesity ( Lindgren et

Free access

Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang and Ming Dong

also a risk factor for metabolic diseases, including type 2 diabetes, obesity and dyslipidaemia ( Tiniakos et al. 2010 ). Thus, NAFLD is often considered as the hepatic manifestation of metabolic syndrome. To date, no effective medical interventions

Free access

Anthony H Tsang, Johanna L Barclay and Henrik Oster

results in metabolic perturbations, and ultimately obesity (reviewed in Froy (2010) ). Conversely, high fat diet (HFD) can dampen clock gene rhythmicity in the liver and fat, and well as affecting behavioral rhythms ( Kohsaka et al . 2007 ). HFD results

Free access

Erica J P Anderson, Isin Çakir, Sheridan J Carrington, Roger D Cone, Masoud Ghamari-Langroudi, Taneisha Gillyard, Luis E Gimenez and Michael J Litt

and energy expenditure, and this role for the receptor has been shown to be evolutionarily conserved in vertebrates from fish to human. MC4R knockout mice as well as human mutants present early onset severe obesity associated with increased fat and

Free access

Thomas Svava Nielsen, Niels Jessen, Jens Otto L Jørgensen, Niels Møller and Sten Lund

essentially unlimited capacity ( Frayn 2002 ). However, the metabolic consequences of an excessive expansion of AT are considerable. In humans, obesity is closely associated with numerous risk factors that constitute the so-called metabolic syndrome. This

Free access

Pilar Argente-Arizón, Santiago Guerra-Cantera, Luis Miguel Garcia-Segura, Jesús Argente and Julie A Chowen

the identification of new therapeutic targets for obesity treatment. It is important to remember that the responses of males and females to obesity and its secondary complications are different ( Palmer & Clegg 2015 ). This is at least partially due

Free access

Laura Marroquí, Alejandro Gonzalez, Patricia Ñeco, Ernesto Caballero-Garrido, Elaine Vieira, Cristina Ripoll, Angel Nadal and Ivan Quesada

situations such as pregnancy or obesity respectively ( Sachdeva & Stoffers 2009 ). The regulation of β-cell function in the short and long term allows for an adequate level of plasma insulin levels, which restores plasma glucose concentrations to

Free access

Xinxin Xiang, Wenjiao An, Changtao Jiang, Jing Zhao, Xian Wang, Guang Sun, Yin Li and Weizhen Zhang

Introduction Inflammation in adipose tissue is intimately linked with the onset and progression of insulin resistance. The link between insulin resistance and obesity is not completely understood. Recent studies suggest that insulin sensitivity is

Open access

Daniela Nasteska and David J Hodson

downregulated/desensitised during obesity/T2DM ( Lynn et al . 2001 , Meier & Nauck 2010 ), stabilised variants of GLP-1 have served as a template for production of incretin mimetics. For an in-depth review of stimulus–secretion coupling in the beta cell, the