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Lena Espelage, Hadi Al-Hasani and Alexandra Chadt

-body glycemia Deficiency in only one of the two RabGAP leads to only moderate impairments in insulin sensitivity and glucose tolerance in rodents, indicating a possible compensatory function of the other respective isoform ( Chadt et al. 2008 , Lansey et

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Adrian J L Clark and Li F Chan

Energy expenditure ↓ No change Movement No change ↑ Insulin +++ ↑ No change Glucose tolerance ↓ at 10–14 weeks No difference 12–28 weeks Response to MTII No response Reduced feeding, same as wild type Bone

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Jessica Sabourin and Florent Allagnat

the risk for developing T2DM. GSIS is also significantly impaired in pancreatic islets from Trpm5 −/− mice, resulting in impaired glucose tolerance. This appears to be due to a lack of glucose-induced fast [Ca 2+ ] i oscillations in those mice. In

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Thomas Svava Nielsen, Niels Jessen, Jens Otto L Jørgensen, Niels Møller and Sten Lund

, high FFA levels attenuate the insulin-mediated suppression of hepatic glucose production contributing to the impairment of whole-body glucose tolerance ( Roden et al . 2000 ). Consistently, improvements in whole-body insulin sensitivity and oral

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Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Carlos Salomon and Martha Lappas

muscle compared to pregnant women with normal glucose tolerance (NGT) ( Shao et al. 2002 , Colomiere et al. 2009 ). However, women with GDM also display a greater proportion of serine phosphorylated IRS-1 ( Shao et al. 2002 , Barbour et al. 2006

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Paola Moreno, Bernardo Nuche-Berenguer, Irene Gutiérrez-Rojas, Alicia Acitores, Verónica Sancho, Isabel Valverde, Nieves González and María L Villanueva-Peñacarrillo

.v. glucose tolerance test (0.05 mg glucose/g of body weight in 30 s) were selected. All rats belonging to the same three groups were of the same age (12–13 weeks old) by the time applying the experimental protocol of the study. Animal housing and protocols

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Neil W Salter, Sudharsana R Ande, Hoa K Nguyen, B L Grégoire Nyomba and Suresh Mishra

for multiple comparisons. P values <0.05 were considered significantly different. Results Reduced insulin secretion from pancreatic islets isolated from TG2-null ( TG2 −/− ) mice TG2 −/− mice have impaired glucose tolerance as a result of reduced

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Michelle Colomiere, Michael Permezel and Martha Lappas

gestational diabetes . American Journal of Physiology 264 E60 – E67 . Catalano PM Huston L Amini SB Kalhan SC 1999 Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational

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J G Miquet, J F Giani, C S Martinez, M C Muñoz, L González, A I Sotelo, R K Boparai, M M Masternak, A Bartke, F P Dominici and D Turyn

slightly better glucose disposal after a glucose load ( Boparai et al . 2010 ). The apparent improvement in glucose metabolism could be attributable to a marked compensatory increase in insulin secretion during the glucose tolerance test and to a favorable

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Jie Sun, Yan Liu, Jinhui Yu, Jin Wu, Wenting Gao, Liyuan Ran, Rujiao Jiang, Meihua Guo, Dongyu Han, Bo Liu, Ning Wang, Youwei Li, He Huang, Li Zeng, Ying Gao, Xin Li and Yingjie Wu

Pharmaceutical Co., Jiangsu, China. Glucose tolerance tests Glucose tolerance test (GTT) was performed after 8 weeks on the diets and again after 10 weeks of gavage. Following an overnight fasting for about 16 h, the mice were subjected to intraperitoneal