Search Results

You are looking at 71 - 80 of 304 items for :

Clear All
Restricted access

Pabitra B Pal, Himangshu Sonowal, Kirtikar Shukla, Satish K Srivastava and Kota V Ramana

cardiovascular homeostasis and act as a physical barrier between lumen and vessel wall. However, oxidative stress induced by oxidants such as hyperglycemia alters phenotypic, metabolic and signaling pathways leading to alteration of normal endothelial cell

Free access

Jerzy-Roch Nofer

-coupled ER (GPR30) has been identified, which is localized in the endoplasmic reticulum and mediates nongenomic estrogen signaling ( Maggiolini & Picard 2010 ). The identity of ER involved in the protective effects against atherosclerosis is not entirely

Free access

Kyounghyun Kim, Robert Burghardt, Rola Barhoumi, Syng-ook Lee, Xinyi Liu and Stephen Safe

reversed by inactivation of p53 ( Jones et al . 1995 , Montes de Oca Luna et al . 1995 , de Rozieres et al . 2000 ). Under conditions of cellular stress, the physical and functional interactions of MDM2 and p53 are inhibited, thereby allowing p53 to

Free access

Jun Yang, Peter J Fuller, James Morgan, Hirotaka Shibata, Colin D Clyne and Morag J Young

), progesterone receptor (PR), androgen receptor (AR), and estrogen receptor (ER) ( Lu et al . 2006 , Griekspoor et al . 2007 ). It is unique in its ability to bind several classes of steroid hormones including the mineralocorticoid aldosterone, and

Free access

Maggie C Evans and Greg M Anderson

). However, the gonadotropin-releasing hormone (GNRH) neurons residing in the hypothalamus are the primary drivers of reproductive function, and impaired GNRH signaling is considered the underlying cause of reproductive suppression due to nutritional stress

Restricted access

Trinidad Raices, María Luisa Varela, Casandra Margarita Monzón, María Florencia Correa Torrado, Romina María Pagotto, Marcos Besio Moreno, Carolina Mondillo, Omar Pedro Pignataro and Elba Nora Pereyra

by histamine, a biogenic amine thoroughly studied by our group and others in the context of LC physiopathology. Oxidative stress is generated by diverse factors such as ionizing and UV radiation, alcohol, metals, aging and others ( Pisoschi & Pop

Free access

Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang and Suhuan Liu

ingredient extracted from the traditional Chinese medicine Radix puerariae , has beneficial effects in protecting various organs survival and possesses anti-oxidative stress ( Hwang & Jeong 2008 , Bebrevska et al . 2010 , Jin et al . 2012 , Zhang et al

Free access

Caroline H Diep, Andrea R Daniel, Laura J Mauro, Todd P Knutson and Carol A Lange

development (reviewed in Brisken & O'Malley (2010) ). Progesterone is a key mediator of mammary gland stem cell expansion ( Brisken 2013 ). In the presence of estrogen, ER-induced expression of PR is required to induce proliferation by both autocrine and

Free access

A R Rodrigues, D Sousa, H Almeida and A M Gouveia

& Fredriksson 2005 , Latek et al . 2012 ). The class A is the largest one and includes all the MCRs. The life cycle of the MCRs is still not deeply characterized but, as for all GPCRs, it is assumed to start in endoplasmic reticulum (ER), undergo several post

Open access

Emma J Agnew, Jessica R Ivy, Sarah J Stock and Karen E Chapman

-derived cardiomyocytes decreased mitochondrial content and activity (as expected) and also reduced concentrations of reactive oxygen species (ROS) and heightened vulnerability to metabolic stress ( Birket et al . 2013 ). This suggests that glucocorticoids, via PGC-1α