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Simona Mencej, Omar M E Albagha, Janez Preželj, Tomaž Kocjan and Janja Marc

implications of genetic variation in non-coding DNA for disease susceptibility and gene regulation . Clinical Science 104 493 – 501 . Lacey DL Timms E Tan HL Kelley MJ Dunstan CR Burgess T Elliott R Colombero A Elliott G Scully S 1998

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Randal C Jaffe, Susan D Ferguson-Gottschall, Weihua Gao, Craig Beam and Asgerally T Fazleabas

reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 144 2870 –2881. Li L , He S, Sun JM & Davie JR 2004 Gene regulation by Sp1 and Sp3. Biochemistry and Cell Biology 82 460

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Xi-Long Zheng and Norman C W Wong

involvement of calcineurin in apo AI gene regulation. To confirm this, we measured the levels of endogenous apo AI protein within cells and in the culture medium in response to various treatments. As anticipated, A23187 increased apo AI in cells and culture

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Caroline H Diep, Andrea R Daniel, Laura J Mauro, Todd P Knutson and Carol A Lange

-regulation of FOXO1 is well defined and prevents FOXO1 nuclear accumulation, thus impairing target gene regulation ( Myatt & Lam 2007 ). As mutations of PI3K s or PTEN are common early events in cancer (particularly in breast, uterine, and ovarian cancers

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A J Notini, R A Davey, J F McManus, K L Bate and J D Zajac

DNA ( Gottlicher et al. 1998 ). This interaction causes the removal of coactivators which normally act to enhance target gene transcription and also results in negative gene regulation. The importance of DNA

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C H J Asbreuk, J H van Doorninck, A Mansouri, M P Smidt and J P H Burbach

-like homeodomain gene expression in the hypothalamus: restricted expression patterns of Rx, Alx4 and goosecoid. Neuroscience 114 883 –889. Burbach JP , Luckman SM, Murphy D & Gainer H 2001 Gene regulation in the magnocellular

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Raffaella Maria Gadaleta and Luca Magnani

transcription factors (COUP-TFs), reverse ERBA-α/-β, liver receptor homologue-1 (LRH1) and others. In this review, we summarize current knowledge regarding the bidirectional crosstalk between NRs and the chromatin landscape in the context of gene regulation

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Shu-Ching M Wang, Dennis H Dowhan and George E O Muscat

to amplify (and modulate) transcriptional regulation ( Lonard & O’Malley 2012 ). This provides additional windows into mechanistic and medicinal targeting of pathways that control gene regulation. Emerging literature has identified a complex interplay

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Dominique H Eghlidi, Vasilios T Garyfallou, Steven G Kohama and Henryk F Urbanski

KB 2002 Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells . Journal of Biological Chemistry 277 5209 – 5218 . ( doi:10.1074/jbc.M110090200 ) 10.1074/jbc.M110090200 Sitzmann BD Brown

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Philippe Huber, Christine Mallet, Elodie Faure, Christine Rampon, Marie-Hélène Prandini, Olivier Féraud, Stéphanie Bouillot and Isabelle Vilgrain

-cadherin-CAT transgenic mice to monitor VE-cadherin gene regulation ( Gory et al. 1999 ). Measurement of CAT activity in several tissues proved to be a very sensitive and reproducible test to monitor VE-cadherin promoter activity. This assay is specific to