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Cristina Velasco, Cristina Otero-Rodiño, Sara Comesaña, Jesús M Míguez and José L Soengas

signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5´monophosphate-activated protein kinase activation . Endocrinology 151 576 – 585 . ( doi:10.1210/en.2009

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Hyon-Seung Yi, Joon Young Chang and Minho Shong

) within the mitochondrial matrix resulted in the mitochondrial-specific upregulation of Hsp60 and Clpp, in the absence of endoplasmic reticulum stress ( Zhao et al . 2002 ). Despite its origins in mammalian cells, mechanistic insight was gained from

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Russell A Prough, Barbara J Clark and Carolyn M Klinge

R) and modulates cellular calcium homeostasis and functions as a chaperone protein in response to endoplasmic reticulum stress ( Maurice 2004 , Hashimoto 2013 , Ruscher & Wieloch 2015 ). Sigma-1 also interacts with PM-bound receptors and ion

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Ana Pestana, João Vinagre, Manuel Sobrinho-Simões and Paula Soares

2014 Endoplasmic reticulum stress activates telomerase . Aging Cell 13 197 – 200 . ( doi:10.1111/acel.12161 ) Zuo QP Liu SK Li ZJ Li B Zhou YL Guo R Huang LH 2011 NF-kappaB p65 modulates the telomerase reverse

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James F H Pittaway and Leonardo Guasti

-o-Acyl transferase 1 triggering lipid-mediated endoplasmic reticulum stress and apoptosis in adrenocortical carcinoma cells . Endocrinology 156 3895 – 3908 . ( ) 10.1210/en.2015-1367 26305886 Sbiera S Sbiera I Ruggiero C

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Xinwang Chen, Xiao Jia, Jie Qiao, Youfei Guan and Jihong Kang

, endoplasmic reticulum stress, defects in leptin-targeted neural circuits, etc. ( Morris & Rui 2009 ). In addition to its critical roles in regulating energy homeostasis, leptin is also important in female reproduction. The deficiency of leptin or LEPR due to

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Custodia García-Jiménez, Jose Manuel García-Martínez, Ana Chocarro-Calvo and Antonio De la Vieja

.08.021 ). Hummasti S Hotamisligil GS 2010 Endoplasmic reticulum stress and inflammation in obesity and diabetes . Circulation Research 107 579 – 591 . ( doi:10.1161/CIRCRESAHA.110.225698 ). Ikeda F Doi Y Yonemoto K Ninomiya T Kubo M Shikata K Hata J Tanizaki Y

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Colin R Jefcoate and Jinwoo Lee

Bose HS 2016 Endoplasmic reticulum stress enhances mitochondrial metabolic activity in mammalian adrenals and gonads . Molecular and Cellular Biology 36 3058 – 3074 . ( ) 27697863 10.1128/MCB.00411

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Yangli Xie, Siru Zhou, Hangang Chen, Xiaolan Du and Lin Chen

, endoplasmic reticulum stress, and cell senescence under both physiological and pathological conditions, but whether FGF signaling also regulate these events in skeletal development and diseases and the underlying mechanisms are still unknown. Numerous variants

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Shoshana Yakar, Haim Werner and Clifford J Rosen

Hunziker EB Yamada Y , 2007 Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function . PLoS Biology 5 e44 . ( ) 10.1371/journal.pbio.0050044 17298185