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Kazue Nagasawa, Christopher Presslauer, Lech Kirtiklis, Igor Babiak and Jorge M O Fernandes

( Ar ) KO mice that lack functional aromatase ( Britt et al . 2001 ) – an alternative model of ER depletion – exhibit abnormal folliculogenesis with seminiferous tube-like structures due to apoptotic granulosa cells ( Drummond & Findlay 1999

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Hyeyeon Ko, WooDong Park, Dae-Jung Kim, Makito Kobayashi and Young Chang Sohn

seabream gradually increased levels of aromatase mRNA during oocyte growth dramatically decreased in follicles at the migratory nucleus and the mature stages ( Gen et al. 2001 ), no effect of r-mtLH on the E2 production by mature follicles of rainbow

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A M Tarrant, S R Greytak, G V Callard and M E Hahn

include lactoferrin, aromatase, small heterodimer partner, endothelial nitric oxide synthase, SULT2A1, and thyroid hormone receptor-α ( Yang et al. 1996 , Vanacker et al. 1998 , Zhang & Teng 2000 , Sanyal et al. 2002 , Sumi & Ignarro 2003

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Marie France Bouchard, Hiroaki Taniguchi and Robert S Viger

steroidogenic pathway such as anti-Müllerian hormone ( Amh ), inhibin subunit α ( Inha ), steroidogenic acute regulatory protein ( Star ), P450 aromatase ( Cyp19a1 ), P450 side chain cleavage ( Cyp11a1 ), P450 17α-hydroxylase/17,20 lyase ( Cyp17a1 ), and 3β

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Joanna E Burdette

imaging and may improve treatment decisions for patients responsive to the therapy ( Van de Wiele et al . 2001 ). Aromatase imaging agents are under investigation preclinically and current options take advantage of binding inhibition to demonstrate where

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Sandra E Ghayad, Julie A Vendrell, Ivan Bieche, Frédérique Spyratos, Charles Dumontet, Isabelle Treilleux, Rosette Lidereau and Pascale A Cohen

. 1991 , Dowsett et al . 2005 ). Two phase III trials have demonstrated that fulvestrant is as efficient as anastrozole, a third-generation aromatase inhibitor, in second-line treatment for postmenopausal women with advanced-stage Tam-resistant breast

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Weiming Zheng, Jingying Yang, Qiaorong Jiang, Zhibin He and Lisa M Halvorson

. 2003 , Hinshelwood et al. 2003 , Pezzi et al. 2004 , Lambard et al. 2005 ). LRH-1, like SF-1, has been demonstrated to stimulate expression of genes which encode steroidogenic enzymes, including the StAR, CYP11A1 and the aromatase genes

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Ye Zhou, Maya Otto-Duessel, Miaoling He, Susan Markel, Tim Synold and Jeremy O Jones

the low-testosterone environment. The changes in the expression of these genes would be predicted to lead to an increased synthesis of testosterone and/or DHT ( Fig. 2 ). Interestingly, the expression of Cyp19a1 , the gene encoding the aromatase

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Sylvia C Hewitt, Wipawee Winuthayanon and Kenneth S Korach

uterine development but exhibit hypoplastic uteri, similar to those of Esr1 −/− . Insensitive to E 2 , infertile Couse et al . (1999) and Dupont et al . (2000) Cyp19a1 −/− (homozygous null aromatase: ArKO) Normal uterine development but exhibits

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Li Zhang, Jie Gao and Sheng Cui

events ( Otsuka et al . 2008 , Donadeu et al . 2012 ). There are scant data about the function of microRNA in the ovary. One such miRNA, miR-378, regulates estradiol production by targeting aromatase ( Xu et al . 2011 ). miR-224 is involved in TGF