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Chunyu Wang, Li Tian, Kun Zhang, Yaxi Chen, Xiang Chen, Ying Xie, Qian Zhao and Xijie Yu

reduces bone mineral density (BMD) in mice ( Halade et al . 2010 ). Obesity affects bone metabolism through several potential mechanisms. It is well known that both adipocytes and osteoblasts are derived from the same progenitor cells: bone marrow

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Weiwei Fan, Annette R Atkins, Ruth T Yu, Michael Downes and Ronald M Evans

∼40% of total body mass and accounts for ∼30% of whole-body energy metabolism during rest ( Zurlo et al . 1990 ). Upon insulin stimulation, skeletal muscle can be responsible for ∼85% of total glucose disposal ( Defronzo et al . 1981 ). During peak

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Evan R Simpson and Kristy A Brown

Introduction Obesity is now recognised to be a low-grade inflammatory condition in which dysregulated metabolism plays an integral role. In this review, we will describe how inflammatory mediators regulate aromatase expression in the human breast as

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Charit Taneja, Sakshi Gera, Se-Min Kim, Jameel Iqbal, Tony Yuen and Mone Zaidi

, and energy metabolism, all of which are most prominent during the late perimenopause ( Perrone et al. 1995 , Ebeling et al. 1996 , Ito et al. 1999 , Chapurlat et al. 2000 , Recker et al. 2000 , Seifert-Klauss et al. 2002 , 2006 ). The

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Ciro Menale, Maria Teresa Piccolo, Grazia Cirillo, Raffaele A Calogero, Alfonso Papparella, Luigi Mita, Emanuele Miraglia Del Giudice, Nadia Diano, Stefania Crispi and Damiano Gustavo Mita

these aspects indicate that BPA exposure, by affecting gene expression, directly regulates adipocyte function and metabolism homeostasis. In this paper, we describe the role of BPA in modulating canonical endocrine function, which regulates metabolism

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Isabel Moscoso, María Cebro-Márquez, Moisés Rodríguez-Mañero, José Ramón González-Juanatey and Ricardo Lage

metabolism deleterious ( Geerling et al. 2014 ). Increased delivery, uptake or decreased FA turnover lead to myocardial lipid accumulation ( Wende & Abel 2010 ) and lipotoxicity ( Wende & Abel 2010 ). Myocardial lipotoxicity is associated to endoplasmic

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Russell A Prough, Barbara J Clark and Carolyn M Klinge

Introduction Metabolism of dehydroepiandrosterone (3β-hydroxy-5-androstene-17-one, DHEA) and its 3β-sulfated metabolite DHEA-S provides ~50% of androgens in men and ~75% of estrogens in premenopausal women ( Maggio et al . 2015 ). Circulating

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Qi Zhang, Qin Zhu, Ruyuan Deng, Feiye Zhou, Linlin Zhang, Shushu Wang, Kecheng Zhu, Xiao Wang, Libin Zhou and Qing Su

Introduction Fibroblast growth factors (FGFs) superfamily has 22 members with diverse biological functions, such as morphogenesis, development, angiogenesis, hematopoiesis, survival and metabolism ( Itoh & Ornitz 2004 , Kharitonenkov 2009

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Inagadapa J N Padmavathi, Kalashikam Rajender Rao and Manchala Raghunath

(Cr), also called glucose tolerance factor, regulates glucose and lipid metabolism ( Mertz 1969 ). Acting as a cofactor for insulin, it enhances glucose utilization by insulin target tissues ( Anderson 1992 ). It facilitates insulin binding to its

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Chen-Tian Shen, Wei-Jun Wei, Zhong-Ling Qiu, Hong-Jun Song, Xin-Yun Zhang, Zhen-Kui Sun and Quan-Yong Luo

, the total number of metformin-used thyroid cancer patients in this study was much small. Targeting cancer cell metabolism has emerged as a novel approach to prevent or treat cancers and one of the primary metabolic changes observed in malignant cell