Search Results

You are looking at 61 - 70 of 212 items for :

  • glucose tolerance x
Clear All
Free access

Yang Mi, Na Guo, Tongqiang He, Jing Ji, Zhibin Li and Pu Huang

/KsJ-Lep db/+ (abbreviated as db/+ ) mouse serves as a promising heterozygous mutant animal model closely mimicking human GDM symptoms ( Kaufmann et al . 1981 ). Prior to pregnancy, they exhibited largely normal glucose tolerance until late gestation

Free access

Xianglan Sun, Ling Gao, Hung-Yu Chien, Wan-Chun Li and Jiajun Zhao

& Rosen 2005 , Woods et al . 2005 ). Overexpression of ARK5 confers tolerance to glucose starvation, which is a stress that leads to a decrease in ATP and an increase in AMP. Therefore, it is probably that insufficient blood supply could lead to hypoxia

Free access

Michelle Colomiere, Michael Permezel and Martha Lappas

tolerance test. Student's t -test * P <0.05 NGT versus GDM-insulin. † P <0.05 NGT (non-obese) versus NGT (obese). Expression studies The effects of GDM in pregnancy on insulin signalling and glucose transport in adipose tissue and skeletal muscle in a non

Open access

Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa and Norimasa Sagawa

% paraformaldehyde (Nakarai Tesque, Kyoto, Japan), and the other tissues were frozen in liquid nitrogen and stored at −80 °C prior to RNA extraction. Metabolic testing For glucose tolerance test (GTT), the mice were deprived of food for 14–16 h overnight and then

Restricted access

Lucia Kořínková, Martina Holubová, Barbora Neprašová, Lucie Hrubá, Veronika Pražienková, Michal Bencze, Martin Haluzík, Jaroslav Kuneš, Lenka Maletínská and Blanka Železná

glucose tolerance test (OGTT) was measured in Experiment 2 ( Fig. 1 ): 6-h-fasted mice were administered a glucose solution at a dose of 2 g/kg BW by gavage. Blood samples were obtained from the tail vessels. The blood glucose concentrations were measured

Free access

Jessica Sabourin and Florent Allagnat

the risk for developing T2DM. GSIS is also significantly impaired in pancreatic islets from Trpm5 −/− mice, resulting in impaired glucose tolerance. This appears to be due to a lack of glucose-induced fast [Ca 2+ ] i oscillations in those mice. In

Free access

Yu-Feng Zhao, Damien J Keating, Maria Hernandez, Dan Dan Feng, Yulong Zhu and Chen Chen

Impaired insulin secretion and glucose tolerance in β cell-selective Ca v 1.2 Ca 2+ channel null mice. EMBO Journal 22 3844 –3854. Tokuyama Y , Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS & Bell GI

Free access

Narudee Kashemsant and Catherine B Chan

glucose tolerance ( Mykkanen et al. 1999 ). Processing of insulin to its mature form involves prohormone-mediated cleavage of C-peptide from proinsulin by subtilisin-like protein convertases (SPCs)-2 and -3 ( Irminger et al. 1996 ). Factors

Free access

C Ruth González, María J Vázquez, Miguel López and Carlos Diéguez

et al . 2006 ). Moreover, ablation of the ghrelin gene improves glucose tolerance, insulin secretion, and insulin sensitivity in genetically leptin-deficient ( ob/ob ) obese mice ( Sun et al . 2006 ). Administration of exogenous ghrelin suppresses

Free access

Laura Marroquí, Alejandro Gonzalez, Patricia Ñeco, Ernesto Caballero-Garrido, Elaine Vieira, Cristina Ripoll, Angel Nadal and Ivan Quesada

better glucose tolerance and insulin sensitivity ( Naito et al . 2011 ). Although it has been reported that leptin affects glucose homeostasis mainly through actions on the hypothalamus ( Coppari et al . 2005 , Huo et al . 2009 , Fujikawa et al