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Tram B Doan, J Dinny Graham and Christine L Clarke

Introduction Breast cancer is the most common cancer diagnosed in women worldwide ( Ferlay et al. 2015 ). Over the past decades, substantial progress toward treatment of primary estrogen receptor-positive (ER+) breast cancer has been made

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Khairul I Ansari, Imran Hussain, Sahba Kasiri and Subhrangsu S Mandal

adenocarcinoma mammary (MCF7), ER-negative human adenocarcinoma mammary (MDA-MB-231), ductal carcinoma mammary (T47D), hepatocellular carcinoma (HEPG2), cervical cancer (HeLa), colorectal adenocarcinoma (SW480), chronic myelogenous leukemia (K562

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Abhi K Rao, Yvonne S Ziegler, Ian X McLeod, John R Yates and Ann M Nardulli

accumulation and its damaging effects, cells express a battery of oxidative stress response proteins that dissipate oxygen radicals ( Halliwell & Gutteridge 1985 , Storz et al . 1990 ). Trx is an oxidative stress response protein that activates i

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Shu-Ching M Wang, Dennis H Dowhan and George E O Muscat

response to endocrine therapy, histological analysis and stratification of breast cancer tumours has been underpinned primarily by measuring the expression of two steroid hormone/nuclear hormone receptors (NRs), ER and the progesterone receptor (PR). In

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Jaya Nautiyal

coregulator that functions both as a coactivator and a corepressor ( Fig. 1 ). It was first identified in human breast cancer cells in a screen to identify interacting partners of the hormone-binding domain of oestrogen receptor α (ER) ( Cavailles et al

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Luis Varela, María J Vázquez, Fernando Cordido, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez and Miguel López

context, increased levels of pFOXO1 after ghrelin treatment elicit a protective effect against lipotoxicity, as shown by inhibition of endoplasmic reticulum (ER) stress and reduced levels of C/EBP homologous protein (CHOP-10; Wang et al . 2010 a ), a pro

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Ulas Ozkurede, Rishabh Kala, Cameron Johnson, Ziqian Shen, Richard A Miller and Gonzalo G Garcia

2016 Anti-cancer effect of cap-translation inhibitor 4EGI-1 in human glioma U87 cells: involvement of mitochondrial dysfunction and ER stress . Cellular Physiology and Biochemistry 40 . ( ) Yi T Kabha E

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Seung Chul Kim, Mee-Na Park, Young Joo Lee, Jong Kil Joo and Beum-Soo An

placenta are associated with complications such as preeclampsia and preterm delivery ( Albrecht & Pepe 2010 ). Estrogen acts by binding to its receptor, estrogen receptor (ER). ER exists in two main forms, ERα (ESR1) and ERβ (ESR2), which have distinct

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R González-Fernández, F Gaytán, E Martínez-Galisteo, P Porras, C A Padilla, J E Sánchez Criado and J A Bárcena

Introduction Reactive oxygen species (ROS) production is a normal process of cell metabolism. The imbalance of the redox status of the cell (oxidative stress), resulting from the accumulation of ROS due to the decrease of antioxidant

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Daniel Raleigh, Xiaoxue Zhang, Benoît Hastoy and Anne Clark

lysosomal storage compartment (lipofuscin bodies). Overexpression (right hand side) of prohIAPP affects trafficking through the ER, overloading the UPR and creating ER stress which can lead to cell death. High concentrations of prohIAPP will aggregate in the