Search Results

You are looking at 61 - 70 of 164 items for :

  • "aromatase" x
Clear All
Free access

Lacey M Litchfield and Carolyn M Klinge

cells in primary culture ( Buholzer et al . 2005 ). COUP-TFII also competed with SF-1 for the human aromatase P450 promoter II in primary endometriotic stromal cells and suppressed aromatase expression ( Zeitoun et al . 1999 ). Overexpression of SF-1

Free access

G Pelletier, V Luu-The, S Li, L Ren and F Labrie

involved in the formation of E 2 in an intracrine fashion ( Labrie 1991 ). It is noteworthy that tissues expressing 17β-HSD type 1 are also expressing aromatase ( Sharpe 1998 , Simpson et al. 2000 ), thus suggesting that E 2 is produced by

Free access

R Mindnich, F Haller, F Halbach, G Moeller, M Hrabé de Angelis and J Adamski

androgen receptor, is a substrate for the 5α-reductase giving rise to the most potent androgen dihydrotestosterone and is a substrate for the aromatase yielding estradiol (for a review on steroid hormone formation see also Payne & Hales 2004 ). The

Free access

Qiongyou Liu, Yang Zhang, Boyang Shi, Huijie Lu, Lihong Zhang and Weimin Zhang

it promotes apoptosis ( Wang & Roy 2007 ), suggesting that regulation of estradiol synthesis is critical in oocyte development. The conversion of estrogens from androgens is catalyzed by an enzyme complex, aromatase, which consists of a flavoprotein

Free access

R Urbatzka, B Watermann, I Lutz and W Kloas

(P450scc), steroidogenic acute regulatory protein (StAR), Srd5a1, Srd5a2 and aromatase (Aro)) in gonad samples. In complement to the analysis of long-term effects of FIN, a short-term exposure was conducted to analyse the transient effects of FIN. The

Free access

Kristy A Brown, Khampoune Sayasith, Nadine Bouchard, Jacques G Lussier and Jean Sirois

follicular steroidogenesis, including the decreased biosynthesis of 17β-estradiol ( Fortune 1994 , Zeleznik 1994 , Murphy 2000 ). The marked decrease in expression of cytochrome P450 enzymes, such as P450 aromatase (CYP19A1) and P450 17α-hydroxylase/C17

Free access

B S Nunez, P M Piermarini, A N Evans and S L Applebaum

consensus poly-adenylation signals ( Nunez & Trant 1998 ). These differences in 3′-UTR length may have an influence on the function of translated enzymes. For example, D. sabina aromatase is encoded by two overlapping transcripts (1700 and 3100 bp

Free access

Paul A Foster and Jonathan Wolf Mueller

Phase II IRIS trial examining the clinical benefit rate of Irosustat combined with aromatase inhibition in advance and metastatic ER+ breast cancer ( Palmieri et al . 2017 a ). Although patient recruitment numbers were relatively low (IPET n  = 13

Free access

Douglas Yee

conversion of precursors into estradiol by aromatase and the disruption of signaling pathways influencing ER have all resulted in new drugs approved to treat breast cancer. There was great hope disruption of the type I insulin-like growth factor receptor

Free access

Carmelo Quarta, Roberta Mazza, Renato Pasquali and Uberto Pagotto

and body weight gain may occur. Indeed, original studies on mice knocked out for the aromatase gene (aromatase is the enzyme responsible for converting androgens to estrogens) revealed that a reduced conversion of androgens into estrogens leads to body