Search Results

You are looking at 51 - 60 of 164 items for :

  • "aromatase" x
Clear All
Free access

Gail P Risbridger, Stuart J Ellem and Stephen J McPherson

-based therapies in the treatment of prostate disease. Aromatase, the enzyme required for metabolism of androgens to estrogens, is expressed in the stroma of the normal prostate ( Ellem et al. 2004 ). Thus, local estrogen signaling, which affects both

Open access

Douglas A Gibson, Paul A Foster, Ioannis Simitsidellis, Hilary O D Critchley, Olympia Kelepouri, Frances Collins and Philippa T K Saunders

et al . 2016 b ). Importantly, we have established that expression of CYP19A1 (aromatase, the key enzyme required for conversion of androgens to estrogens) as well as AKR1C3 and SRD5A1 (enzymes that convert precursor androgens into

Free access

Ronald M Evans

to and augments the severity of the disease. Evan Simpson reviews how chronic inflammation associated with high fat diet disrupts the normally tight regulation of the aromatase gene. Aromatase is involved in the biosynthesis of estrogen, the ligand

Free access

Camille Bois, Christelle Delalande, Hélène Bouraïma-Lelong, Philippe Durand and Serge Carreau

et al . 1997 , Franca et al . 1998 , McLachlan et al . 2002 ). Among these factors, there is growing evidence that estrogens, synthesized by the cytochrome P450 aromatase, could be concerned with the regulation of spermatogenesis (for review

Free access

Barry V L Potter

. 2013 ). In recent decades, however, inhibitors of oestrogen biosynthesis targeting the aromatase enzyme, aromatase inhibitors (AIs), have become the new gold standard for treatment of hormone-dependent breast cancer and the so-called ‘third generation

Free access

Denise Vizziano-Cantonnet, Daniel Baron, Sophie Mahè, Chantal Cauty, Alexis Fostier and Yann Guiguen

direct estrogen treatments ( Yao 2005 ). However, in mice knockout models (KO) either for aromatase ( Cyp19a ) enzyme (ArKO) or for estrogen receptors α and β (ERαβKO), females are unable to synthesize estrogens, or to respond to the estrogenic signal

Free access

J J Allen, S L Herrick and J E Fortune

FSH stimulates granulosa cells to convert thecal androgens to estrogens via the enzyme aromatase (reviewed in Fortune & Quirk 1988 ). Immunohistochemical studies localized protein for aromatase in fetal bovine ovaries between 45 and 250 days of

Free access

J M Torres and E Ortega

cortex have not been measured in this work. It is generally accepted that the aromatase enzyme depends on the androgenic status of animals. Thus, castration decreases aromatase activity and mRNA levels, whereas T treatment restores them ( Harada et al

Free access

Chunmei Wang and Yong Xu

ovary. Androgens, mainly testosterone and androstenedione, can be converted to estrogens by aromatase ( Jarvie & Hentges 2012 ). Thus, even in males, despite the low circulating levels of estrogens, estrogens can be produced through local aromatization

Free access

Douglas A Gibson, Ioannis Simitsidellis and Philippa T K Saunders

pregnancy. (C) Regulation of testosterone bioavailability may also impact on the regulation of the endometrium by acting as a precursor to oestrogens. Following induction of aromatase expression in decidualised ESCs ( Gibson et al . 2013 ), local oestrogens