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Guoying Chang, Rui Yang, Yanan Cao, Aifang Nie, Xuefan Gu and Huiwen Zhang

levels and impaired glucose tolerance ( Gao et al . 2013 ). Islets from Sidt2 −/− mice cultured in vitro produced less insulin when stimulated with a high concentration of glucose or a depolarizing concentration of KCl. Under physiological

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Marloes Dekker Nitert, Cecilia L F Nagorny, Anna Wendt, Lena Eliasson and Hindrik Mulder

secretion is defective in the pre-diabetic stage of impaired glucose tolerance ( Hosker et al . 1989 , Tripathy et al . 2000 , Abdul-Ghani et al . 2006 ), and an absolute decompensation of β-cell function characterises the transition to mild diabetes

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Haoyong Yu, Mingliang Zhang, Yunqin Ma, Junxi Lu, Jiemin Pan, Pan Pan, Haibing Chen and Weiping Jia

 h) to measure fasting glucose levels using the ACCU-CHEK glucometer (Roche diagnostics) once a week during the entire duration of study. Insulin tolerance tests (ITT) were performed on the 8th week of treatment. Before ITT, mice were fasted for 6 h

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Custodia García-Jiménez, Jose Manuel García-Martínez, Ana Chocarro-Calvo and Antonio De la Vieja

impaired glucose tolerance, without diabetes, is associated with increased cancer risk ( Dankner et al . 2007 ), hyperglycemia inexorably induces increased insulin secretion unless there is a defect in insulin production or secretion. Hyperinsulinemia

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C Attané, D Daviaud, C Dray, R Dusaulcy, M Masseboeuf, D Prévot, C Carpéné, I Castan-Laurell and P Valet

subjects ( Boucher et al . 2005 , Castan-Laurell et al . 2008 ). Plasma apelin levels are also raised in morbidly obese ( Heinonen et al . 2005 ) and type 2 diabetic ( Soriguer et al . 2009 ) subjects. Nonobese patients with impaired glucose tolerance

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Z López-Ibarra, J Modrego, M Valero-Muñoz, P Rodríguez-Sierra, J J Zamorano-León, A González-Cantalapiedra, N de las Heras, S Ballesteros, V Lahera and A J López-Farré

. ( doi:10.1136/jmg.31.11.875 ). Bukowiecki LJ 1989 Energy balance and diabetes: the effects of cold exposure, exercise training, and diet composition on glucose tolerance and glucose metabolism in rat peripheral tissues . Canadian Journal of

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Hamedeh Ghanaat-Pour, Zhen Huang, Mikael Lehtihet and Åke Sjöholm

V, Efendic S & Ostenson CG 1994 Impact of diabetic inheritance on glucose tolerance and insulin secretion in spontaneously diabetic GK-Wistar rats. Diabetes 43 281 –288. Acton RT , Roseman JM, Bell DS, Goldenberg RL

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Gerald Thiel, Isabelle Müller and Oliver G Rössler

impaired glucose tolerance ( Uchida et al . 2011 ). TRPM5 channels are important constituents of Ca 2 + -activated cation current in β-cells. Correspondingly, reduced channel activity could be measured in β-cells of TRPM5-deficient mice ( Colsoul et al

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Jianling Xie, Norhan M El Sayed, Cheng Qi, Xuechan Zhao, Claire E Moore and Terence P Herbert

regulation of β-cell growth, as β-cell-specific S6K1 knockout mice have comparatively smaller β-cells compared with WT mice, which coincides with hypoinsulinemia and impaired glucose tolerance ( Pende et al . 2000 , Ruvinsky et al . 2005 ). Our aim was to

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Eva Tudurí, Monica Imbernon, Rene Javier Hernández-Bautista, Marta Tojo, Johan Fernø, Carlos Diéguez and Rubén Nogueiras

.1 µmol/kg, i.p. Increased GSIS and improved glucose tolerance McKillop et al . (2016) GLP-1 −/− mice Abn-CBD Agonist 2.5, >30, >30 μM 0.1 µmol/kg, i.p. No effects on GSIS or glucose tolerance McKillop et al . (2016) GPR