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Mohamed H Noureldein, Sara Bitar, Natalie Youssef, Sami Azar and Assaad A Eid

, Khan & Jena 2014 , 2015 , Meier & Wagner 2014 , Dirice et al. 2017 ), which can explain the alteration in the inflammatory markers observed in diabetes. Furthermore, another mechanistic factor that has been shown to play a role in inflammation is

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Ralf Stumm and Volker Höllt

relevance ( Stumm et al. 2002 ). This is emphasized by the fact that SDF-1 limits cerebral inflammation during experimental autoimmune encephalomyelitis by keeping CXCR4-expressing mononuclear cells in the perivascular space and thereby limiting

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Yihong Wan and Ronald M Evans

PPARδ to inhibit FKN transcription. Emerging evidence reveals that PPARγ is a key regulator of both lipid metabolism and inflammation. The ability to integrate metabolic signaling and inflammatory signaling makes PPARγ an attractive target for

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Xueyao Yin, Fenping Zheng, Qianqian Pan, Saifei Zhang, Dan Yu, Zhiye Xu and Hong Li

). Similarly, cleaved caspase 3, cleaved caspase 9, Bax, CHOP and PUMA were also significantly increased in the liver of mice fed a HFD, which was further exacerbated by glucose injections ( Fig. 3 D). Glucose fluctuation exacerbates liver inflammation and

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Rebecca H Ritchie, Eser J Zerenturk, Darnel Prakoso and Anna C Calkin

promoting inflammation, apoptosis and hypertrophy ( Goldberg et al . 2012 ). The promotion of insulin resistance drives a further increase in insulin levels, which have pathological effects on the heart per se . FAs can also influence contractility as

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N Martínez-Micaelo, N González-Abuín, A Ardévol, M Pinent, E Petretto, J Behmoaras and M Blay

Introduction A prolonged excess of nutrient consumption results in the continuous saturation of the white adipose tissue's ability to store energy as fat, triggering a cytokine-driven response that underlie an obesity-induced inflammation. Thus

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Matthias Laudes

signalling in humans is not only important in adipose tissue development but also in pancreatic islet biology ( Lyssenko et al . 2007 ). WNT molecules and low-grade inflammation of adipose tissue Infiltration of adipose tissue by macrophages and lymphocytes

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Rajaa El Bekay, Gonzalo Alba, M Edith Reyes, Pedro Chacón, Antonio Vega, José Martín-Nieto, Juan Jiménez, Eladio Ramos, Josefina Oliván, Elízabeth Pintado and Francisco Sobrino

pathogenesis of vascular diseases ( Mazzone et al . 1993 ). Given that chronic inflammation of vessel walls is a pathological indicator of hypertension ( Touyz 2003 ) and that reactive oxygen species (ROS) such as superoxide anion and H 2 O 2 constitute the

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Dong-Jae Jun, Kyung-Yoon Na, Wanil Kim, Dongoh Kwak, Eun-Jeong Kwon, Jong Hyuk Yoon, Kyungmoo Yea, Hyeongji Lee, Jaeyoon Kim, Pann-Gill Suh, Sung Ho Ryu and Kyong-Tai Kim

regulator of inflammation, p38 integrates inflammatory responses by regulating several aspects of target gene transcription and translation. p38 enhances both the transcriptional activity of NFκB via acetylation of p65 ( Saha et al . 2007 ) and the

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Huan Zhang, Xiuxia Liu, Shanshan Zhou, Ye Jia, Ying Li, Yuguo Song, Junnan Wang and Hao Wu

, Periodic acid-Schiff; UACR, urinary albumin to creatinine ratio; WT, wild type. NRF2 was required for SP600125’s alleviation of the diabetes-induced renal oxidative stress, inflammation and fibrosis Renal nitrosative damage was reflected by