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Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

G proteins and other components of the CaSR signal transduction pathway ( Leach et al . 2012 ). Some loss-of-function CaSR mutations have been shown to cause signalling bias by switching the wild-type CaSR from preferentially coupling with

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Sonia D'Inzeo, Arianna Nicolussi, Antonella Ricci, Patrizia Mancini, Antonio Porcellini, Francesco Nardi and Anna Coppa

the ability to become, at least partially, resistant to growth inhibition, to proliferate without dependence on growth factors, to replicate without limit, to invade, and to metastasize. TGFβ is one of the complex signal transduction pathways that

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Jarrod Bailey, Alison J Tyson-Capper (née Pollard), Kate Gilmore, Stephen C Robson and G Nicholas Europe-Finner

of which is linked to gestational physiological processes such as tissue, extracellular matrix and cytoskeletal remodelling, signal transduction, activity of cytokines, hormones and their receptors, and of course muscular contractility. They also

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Cecilia Verga Falzacappa, Eleonora Petrucci, Valentina Patriarca, Simona Michienzi, Antonio Stigliano, Ercole Brunetti, Vincenzo Toscano and Silvia Misiti

receptors for the hormone that may be linked to signal transduction pathways. Membrane-binding sites for thyroid hormones were identified years ago in cell membranes isolated from human and rat hepatocytes ( Gharbi & Torresani 1979 , Pliam & Goldfine 1997

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H K Kinyamu, J Chen and T K Archer

polymerase II in Saccharomyces cerevisiae. Molecular and Cellular Biology 19 6972 –6979. Bech-Otschir D , Seeger M & Dubiel W 2002 The COP9 signalosome: at the interface between signal transduction and ubiquitin

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F Al-Khafaji, M Wiltshire, D Fuhrer, G Mazziotti, M D Lewis, P J Smith and M Ludgate

means of investigating the prolonged effects of iodide on the proliferation, signal transduction and cell cycle profiles of thyroid cells expressing TSHR gain-of-function mutations. We now report our findings of these investigations

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L Couture, H Naharisoa, D Grebert, J-J Remy, E Pajot-Augy, V Bozon, T Haertle and R Salesse


The LH/hCG receptor is a G protein-coupled receptor with an N-terminal extracellular domain involved in hormone—receptor interaction. The recombinant porcine receptor, stably expressed in Chinese hamster ovary (CHO) cells, has the same characteristics (K d and cAMP production) as in Leydig cells. Six synthetic peptides derived from the receptor ectodomain and two polyclonal anti-peptide sera were tested in the homologous system porcine LH and porcine LH receptor. Their ability to inhibit hormone binding and signal transduction on CHO cells expressing the recombinant receptor was evaluated. Peptides 25–40 and 107–121 exhibited a high transduction inhibition as compared with hormone binding, peptides 21–36, 102–111, and 102–121 inhibited hormone binding more efficiently than signal transduction, and peptide 7–24 exhibited inhibition of both hormone binding and hormone-induced cAMP production. Immuno-globulins against peptides 21–36 and 102–111 inhibited both hormone binding and receptor activation suggesting that these sequences are located on the receptor surface.

The data suggest that multiple, discontinuous regions of the extracellular domain of porcine LH receptor are involved in hormone binding and signal transduction. Two minimum critical sequences, 21–24 and 102–107, are involved in hormone binding and vicinal segments may be implicated in signal transduction.

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Ingrid Langer, Christelle Langlet and Patrick Robberecht

the basis of extensive study of the largest family of GPCRs also called the GPCR-A/rhodopsin family ( Ferguson 2001 , Kohout & Lefkowitz 2003 , Perry & Lefkowitz 2002 , Wess 1997 ). The mechanisms regulating the GPCR-B family signal transduction are

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Maciej Pietrzak and Monika Puzianowska-Kuznicka

figure represents the mean results of nine experiments, ± s.d . Discussion In this work, we showed that MCL-1, an anti-apoptotic member of the BCL-2 family, is activated by T 3 using a non-genomic mechanism that involves the PI3-K signal transduction

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Jürgen M Weiss, Heike Hüller, Stephan Polack, Michael Friedrich, Klaus Diedrich, Oliver Treeck, Georg Pfeiler and Olaf Ortmann

transduction such as calcium signaling and inositol phosphates are in part responsible for the effects of estradiol ( Ortmann et al. 1992 , 1995 ). It might well be that steroids affects late steps in GnRH signal transduction like exocytosis ( Ortmann et al