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M Blandino-Rosano, G Perez-Arana, J M Mellado-Gil, C Segundo and M Aguilar-Diosdado

machinery, which acts upon G2/M and more importantly on G1/S checkpoints, includes elements such as pRb (protein defective in human retinoblastoma), some cyclins, and cyclin-dependent kinases (For an extensive review see Cozar-Castellano et al . 2006

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Inga K Johnsen and Felix Beuschlein

Ghosh Choudhury G 2000 Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation . Biochemical and Biophysical Research

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Kyounghyun Kim, Robert Burghardt, Rola Barhoumi, Syng-ook Lee, Xinyi Liu and Stephen Safe

number of p53-independent functions of MDM2 have been identified and show that this protein can modify different signaling pathways. MDM2 interacts with and inhibits the function of retinoblastoma (Rb) protein and other Rb family members ( Hsieh et al

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Neil W Salter, Sudharsana R Ande, Hoa K Nguyen, B L Grégoire Nyomba and Suresh Mishra

. Mishra S Melino G Murphy LJ 2007a Transglutaminase 2 kinase activity facilitates protein kinase A induced phosphorylation of retinoblastoma protein . Journal of Biological Chemistry 282 18108 – 18115 . doi:10.1074/jbc.M607413200 . Mishra

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I J Bujalska, M Quinkler, J W Tomlinson, C T Montague, D M Smith and P M Stewart

, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. American Journal of Respiratory Cell and Molecular Biology 21 77 –88

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Abhi K Rao, Yvonne S Ziegler, Ian X McLeod, John R Yates and Ann M Nardulli

-Norton JR Ziegler YS McLeod IX Yates JR Nardulli AM 2008 The role of retinoblastoma associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression . Molecular and Cellular Endocrinology 291 79 – 86 . Curtis CD Likhite

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Yajie Guo, Junjie Yu, Chunxia Wang, Kai Li, Bin Liu, Ying Du, Fei Xiao, Shanghai Chen and Feifan Guo

M Wang Q Zhao M Xu X Liu Z Li W Liu S 2013 Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212 . PLoS ONE 8 e69784 . ( doi:10

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Endong Zhu, Juanjuan Zhang, Jie Zhou, Hairui Yuan, Wei Zhao and Baoli Wang

adipogenesis by suppressing various target genes associated with adipogenic differentiation. For instance, miR-17-92 cluster, miR-204, miR-30e, miR-223 and miR-148a-3p promote adipocyte differentiation by negatively regulating retinoblastoma family (pRb) gene

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Chanchal Gupta and Kulbhushan Tikoo

hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression . Biomedicine & Pharmacotherapy 62 85 – 93 . ( doi:10.1016/j.biopha.2007.06.002 ). Weichhaus M Broom J Wahle K

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Young Sun Kang, Yun Gyu Park, Bo Kyung Kim, Sang Youb Han, Yi Hwa Jee, Kum Hyun Han, Mi Hwa Lee, Hye Kyoung Song, Dae Ryong Cha, Shin Wook Kang and Dae Suk Han

pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2 stimulated T cells independently of p38 mitogen-activated protein