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Fei Xiao, Ying Du, Ziquan Lv, Shanghai Chen, Jianmin Zhu, Hongguang Sheng and Feifan Guo

& Scherer 2009 ). The effects of fat and glucose on lipid metabolism regulation have been well known; however, the effects of AAs are poorly understood. AAs are the building blocks of proteins and have also been shown to regulate many cell signaling pathways

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Chikahito Suda, Junichi Yatabe, Midori Yatabe, Miki Yarita and Atsuhiro Ichihara

S 2015 ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 beta subunit . Journal of Biological Chemistry 9690 – 9700 . ( ) Kim JW Tchernyshyov

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Nora Martínez, Melisa Kurtz, Evangelina Capobianco, Romina Higa, Verónica White and Alicia Jawerbaum

Introduction Maternal diabetes impairs fetal and placental development, metabolism, and growth. Both type 1 and type 2 diabetes increase the risks of miscarriage and malformations ( Balsells et al . 2009 , Michael Weindling 2009 ). Gestational

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Matias Knuuttila, Esa Hämäläinen and Matti Poutanen

Development of highly sensitive mass spectrometric assays for analyzing androgens in body fluids and tissues To provide solid evidence for the role of local steroid metabolism as a key regulatory step in sex steroid biology we and several

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Leping Zhao, Yong Pan, Kesong Peng, Zhe Wang, Jieli Li, Dan Li, Chao Tong, Yi Wang and Guang Liang

this figure is available at . Administration of LG13 lowered fasting blood glucose, and improved glucose tolerance and hepatic glucose metabolism in type 2 diabetic mice To validate the beneficial effects of LG13

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David R Clemmons

signaling systems. An additional concept that is important for understanding the ability of the IGFBPs to regulate metabolism is the distinction between locally secreted BPs (autocrine/paracrine effects) and IGFBP actions that are mediated via

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Jaya Nautiyal

. Examination of the heart tissue in these mice demonstrated mitochondrial degeneration and reduced expression of genes involved in mitochondrial activity, fatty acid metabolism and transport and impaired signalling of nuclear receptors, PPARα, PPARδ, oestrogen

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Sachie Nakamichi, Yoko Senga, Hiroshi Inoue, Aki Emi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa and Masato Kasuga

Introduction The liver plays a central role in nutrient metabolism. It stores carbohydrate as glycogen in the fed state, and it releases glucose, produced either through the breakdown of glycogen (glycogenolysis) or through de novo synthesis

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B Elo, C M Villano, D Govorko and L A White

physiological functions ( Gnugge et al. 2004 ). The endocrine tissue is critical for the regulation of glucose metabolism through secretion of insulin, somatostatin, and glucagon directly into the bloodstream. The exocrine portion of the pancreas produces

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Suryaprakash Raichur, Patrick Lau, Bart Staels and George E O Muscat

Introduction Nuclear hormone receptors (NRs) have been demonstrated to regulate metabolism in an organ-specific manner. The importance of NRs in the context of promoting and maintaining human health is underscored by the therapeutic