Search Results

You are looking at 31 - 40 of 497 items for :

Clear All
Free access

Karen Oliva, Gillian Barker, Clyde Riley, Mark J Bailey, Michael Permezel, Gregory E Rice and Martha Lappas

Introduction There is no disputing the extent of the worldwide obesity epidemic ( Chu et al . 2008 , Colagiuri et al . 2010 ). The proportion of women who are obese at the beginning of pregnancy has dramatically increased ( Heslehurst et al

Free access

Michelle Colomiere, Michael Permezel and Martha Lappas

their offspring have greater incidence of perinatal complications and increased risk of obesity and diabetes in adulthood ( Metzger 2007 ). Blood glucose levels are regulated by the insulin-signalling pathway. The β-cells of the pancreas secrete insulin

Free access

Manuela Cabiati, Serena Raucci, Chiara Caselli, Maria Angela Guzzardi, Andrea D'Amico, Tommaso Prescimone, Daniela Giannessi and Silvia Del Ry

Introduction Obesity is a chronic, multifactorial, and complex disease resulting from environmental and genetic factors. The progression of this pathology has been associated with an increased predisposition for developing additional morbid

Free access

S M Jeyakumar, A Vajreswari, B Sesikeran and N V Giridharan

Introduction Obesity is a condition where excess energy is stored as triglycerides in white adipose tissue (WAT) ( Palou et al. 2000 ). WAT, the major component of the adipose organ, is widely distributed in the mammalian body in

Free access

O Verlaeten, C Casery, S Cavagna, D Naville, P Giraudon, M F Belin, M Begeot and A Bernard

Introduction The maintenance of body weight around a set point requires a long-term balance between energy intake and expenditure, and depends on tightly regulated interactions between the nervous and the endocrine systems. Obesity

Free access

Yanjun Liu, Yuichi Nakagawa, Ying Wang, Limei Liu, Hongwei Du, Wei Wang, Xiuhai Ren, Kabirullah Lutfy and Theodore C Friedman

Introduction Excess glucocorticoid (GC) production (Cushing's syndrome) induces obesity and insulin resistance via activation of intracellular GC receptor (GR; Rizza et al . 1982 , Friedman et al . 1993 ). The GR belongs to a cytoplasmic nuclear

Free access

Adrian J L Clark

hypothalamus, and MC2 receptors in the adrenal cortex, it is no surprise that α-MSH and ACTH deficiency give rise to pigmentation abnormalities, obesity, and adrenal insufficiency, respectively, in homozygous animals. There are, however, some subtle and

Free access

Suzy S J Hur, Jennifer E Cropley and Catherine M Suter

& Osmond 1986 , Barker et al . 1989 ), it is overnutrition that is most pertinent in current times. Global obesity rates have grown steadily over the last four decades, and weight increases in the reproductive ages are prominent, even in low-middle income

Free access

L J Moran, P A Mundra, H J Teede and P J Meikle

underpinned by genetic abnormalities and exacerbated by obesity. Its key pathophysiological features are abnormalities in insulin resistance (IR) ( Stepto et al . 2013 ) (75% of lean and 95% of overweight and obese women affected) and hyperandrogenism (80

Free access

Louise Ruby Høj Illum, Stine Thorhauge Bak, Sten Lund and Anders Lade Nielsen

activity through ZFP57/TRIM28 is tightly associated with the existence of H3K9me3 in imprinted genomic regions ( Messerschmidt et al . 2012 ). Decreased TRIM28 expression in mice during development is linked to an increased risk of obtaining an obese