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Hanze Du, Limei Liu, Ying Wang, Yuichi Nakagawa, Alexei Lyzlov, Kabirullah Lutfy, Theodore C Friedman, Xiaozhong Peng and Yanjun Liu

Introduction Obesity and type 2 diabetes has reached epidemic prevalence worldwide emphasizing the urgent need for the underlying mechanisms of this disease to lead to new treatment. Glucocorticoids are steroid hormones and chronic elevation of

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S M Jeyakumar, A Vajreswari, B Sesikeran and N V Giridharan

Introduction Obesity is a condition where excess energy is stored as triglycerides in white adipose tissue (WAT) ( Palou et al. 2000 ). WAT, the major component of the adipose organ, is widely distributed in the mammalian body in

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O Verlaeten, C Casery, S Cavagna, D Naville, P Giraudon, M F Belin, M Begeot and A Bernard

Introduction The maintenance of body weight around a set point requires a long-term balance between energy intake and expenditure, and depends on tightly regulated interactions between the nervous and the endocrine systems. Obesity

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Yanjun Liu, Yuichi Nakagawa, Ying Wang, Limei Liu, Hongwei Du, Wei Wang, Xiuhai Ren, Kabirullah Lutfy and Theodore C Friedman

Introduction Excess glucocorticoid (GC) production (Cushing's syndrome) induces obesity and insulin resistance via activation of intracellular GC receptor (GR; Rizza et al . 1982 , Friedman et al . 1993 ). The GR belongs to a cytoplasmic nuclear

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Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu and Bo Yu

The prevalence of obesity is dramatic increased and strongly associated with cardiovascular disease. Adipokines, secreted from adipose tissues, are critical risk factors for the development of cardiomyopathy. Present study aimed to investigate the pathophysiological role of autotaxin in obesity-related cardiomyopathy. In high fat diet-fed mice, autotaxin was mainly synthesized and secreted from adipocytes. The increased accumulation of cardiac autotaxin was positively associated with cardiac dysfunction in obese mice. Interestingly, specific blockage of adipose tissue autotaxin effectively protected against high fat diet-induced cardiac structural disorders, left ventricular hypertrophy and dysfunction. Inhibition of autotaxin further improved high fat diet-induced cardiac fibrosis and mitochondrial dysfunction, including improvement of mitochondrial structure, mass and activities. Our findings demonstrated intervention of adipose tissue biology could influence cardiac modification in obese mice, and adipocyte-derived autotaxin was a potential diagnostic marker and therapeutic target for obesity-related cardiomyopathy.

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Adrian J L Clark

hypothalamus, and MC2 receptors in the adrenal cortex, it is no surprise that α-MSH and ACTH deficiency give rise to pigmentation abnormalities, obesity, and adrenal insufficiency, respectively, in homozygous animals. There are, however, some subtle and

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Suzy S J Hur, Jennifer E Cropley and Catherine M Suter

& Osmond 1986 , Barker et al . 1989 ), it is overnutrition that is most pertinent in current times. Global obesity rates have grown steadily over the last four decades, and weight increases in the reproductive ages are prominent, even in low-middle income

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L J Moran, P A Mundra, H J Teede and P J Meikle

underpinned by genetic abnormalities and exacerbated by obesity. Its key pathophysiological features are abnormalities in insulin resistance (IR) ( Stepto et al . 2013 ) (75% of lean and 95% of overweight and obese women affected) and hyperandrogenism (80

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Louise Ruby Høj Illum, Stine Thorhauge Bak, Sten Lund and Anders Lade Nielsen

activity through ZFP57/TRIM28 is tightly associated with the existence of H3K9me3 in imprinted genomic regions ( Messerschmidt et al . 2012 ). Decreased TRIM28 expression in mice during development is linked to an increased risk of obtaining an obese

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Junye Chen, Yi Lu, Mengyuan Tian and Qiren Huang

Introduction Obesity is considered to be a syndrome involving chronic and low-level inflammatory response characterized by abnormal production of cytokines and activation of the inflammatory response signalling pathway in adipose tissues