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Feng Wang, Lu Wang, Yifeng Wang, Dai Li, Tianpeng Hu, Manyi Sun and Ping Lei

risk of mild cognitive impairment ( Wang et al . 2017 a , b , c ). Furthermore, it is believed that oxidative stress and inflammation caused by metabolic disorders lead to the quantity reduction and dysfunction of hippocampus neurons, which may

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Rong Wan, Yunxin Liu, Li Li, Chao Zhu, Lai Jin and Shengnan Li

Introduction Cardiovascular diseases are the leading fatal diseases. Increased evidence shows that vascular inflammation plays a key role in the initiation and progression of many diseases, including atherosclerosis ( Ricciotti & FitzGerald 2011

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Custodia García-Jiménez, Jose Manuel García-Martínez, Ana Chocarro-Calvo and Antonio De la Vieja

population may be attributed to treatment for diabetes, to hormonal disorders, to the status of chronic inflammation and to metabolic alterations underlying the diseases (summarized in Fig. 1 ). Moreover, diabetes may also develop following tumor

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Ting Qi, Yanming Chen, Honggui Li, Ya Pei, Shih-Lung Woo, Xin Guo, Jiajia Zhao, Xiaoxian Qian, Joseph Awika, Yuqing Huo and Chaodong Wu

Introduction Chronic low-grade adipose tissue inflammation is a characteristic of obesity ( Lumeng et al. 2007 , Weisberg et al. 2003 , Xu et al. 2003 ) and critically contributes to the pathogenesis of type 2 diabetes ( Greenberg

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Michael Wöltje, Beate Tschöke, Verena von Bülow, Ralf Westenfeld, Bernd Denecke, Steffen Gräber and Willi Jahnen-Dechent

% liver-derived. Thus, Ahsg is a major hepatic serum protein. A thorough understanding of Ahsg gene regulation during inflammation and recovery is important for several reasons. A well-documented physiological function of Ahsg is the systemic inhibition of

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Laura Calzà, Mercedes Fernandez and Luciana Giardino

among young adults, with 12 000 new diagnoses per year in the United States alone ( Hirtz et al . 2007 ). Different pathogenic events involving many cell types occur in the course of the disease. According to the classical view, inflammation and immune

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Irit Hochberg, Innocence Harvey, Quynh T Tran, Erin J Stephenson, Ariel L Barkan, Alan R Saltiel, William F Chandler and Dave Bridges

ceramide species ( Fig. 7 B, q >0.25). Inflammation Several pathways involved in immune function were downregulated in the adipose tissue from Cushing's disease patients. This is consistent with the effects of cortisol in suppressing immune function

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Salman Azhar, Dachuan Dong, Wen-Jun Shen, Zhigang Hu and Fredric B Kraemer

led to clear understanding that miRNAs contribute to the regulation of a variety of physiologic processes including embryonic development, differentiation and proliferation, apoptosis, metabolism, hemostasis and inflammation ( Bushati & Cohen 2007 , O

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Yan-hui Bai, Yong Lv, Wei-qun Wang, Guang-li Sun and Hao-hao Zhang

cell wall in gram-negative bacteria, and it induces inflammation by promoting the secretion of cytokines, including TNF-α, IL-6 and vascular endothelial growth factor ( Marton et al. 2014 , Yang et al. 2014 ). LPS is often used to stimulate HCFs

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Maria Jacoba Kruger, Maria Martha Conradie, Magda Conradie and Mari van de Vyver

signalling pathways that contribute to the pathogenesis of chronic inflammation and hyperglycaemia ( Chen et al. 2016 , Fontaine et al. 2016 , Zachar et al. 2016 , Harting et al. 2018 ). A reduction in the size of the circulating stem