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Kira Meyerovich, Fernanda Ortis and Alessandra K Cardozo

-like receptor activation and/or endoplasmic reticulum stress may also induce NF-κB activation in these cells ( Meyerovich et al . 2016 b ). NF-κB inhibition renders human and rodent islets resistant to cytokine-induced β-cell apoptosis in vitro

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Yanning Li, Yan Zhong, Wenjian Gong, Xuehan Gao, Huanli Qi, Kun Liu and Jinsheng Qi

.1530/JOE-16-0205 Fan Y Zhang J Xiao W Lee K Li Z Wen J He L Gui D Xue R Jian G , 2017 Rtn1a-mediated endoplasmic reticulum stress in podocyte injury and diabetic nephropathy . Scientific Reports 7 323 . ( https://doi.org/10

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Jiazhong Sun, Yancheng Xu, Haohua Deng, Suxin Sun, Zhe Dai and Yanlei Sun

tumor necrosis factor-α and interleukin-6, and reactive oxygen species (ROS) have been shown to increase expression of adipokines in adipocytes ( Lin et al . 2005 ). Oxidative stress, endoplasmic reticulum stress, and nuclear factor kappa B (NF

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Laura de Miguel-Santos, Elisa Fernández-Millán, María Ángeles Martín, Fernando Escrivá and Carmen Álvarez

non-esterified fatty acids (NEFA)- or endoplasmic reticulum stress-induced apoptosis ( Srinivasan et al . 2005 , Mussmann et al . 2007 ). Certainly, GSK-3 may not be the only mediator of the partial suppression of β-cell apoptosis observed in

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Lai Jin, Chuanhua Li, Rong Li, Zongxing Sun, Xianjun Fang and Shengnan Li

TNF-induced apoptosis ( Wissing et al . 1997 , Pilane & LaBelle 2002 ). Recent data reported that cPLA 2 induced endoplasmic reticulum stress by the complement membrane attack complex ( Ren et al . 2010 ). However, there is no clear consensus as to

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Qi Zhang, Qin Zhu, Ruyuan Deng, Feiye Zhou, Linlin Zhang, Shushu Wang, Kecheng Zhu, Xiao Wang, Libin Zhou and Qing Su

implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H . Hepatology 48 1242 – 1250 . ( https://doi.org/10.1002/hep.22439 ) 18704925 10

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Özlem Erdogdu, Linnéa Eriksson, Hua Xu, Åke Sjöholm, Qimin Zhang and Thomas Nyström

pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB . Diabetes 58 2851 – 2862 . ( doi:10.2337/db09-0685 ). Dimmeler S Zeiher AM 1999 Nitric oxide-an endothelial cell survival factor . Cell Death

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Laura Marroquí, Alejandro Gonzalez, Patricia Ñeco, Ernesto Caballero-Garrido, Elaine Vieira, Cristina Ripoll, Angel Nadal and Ivan Quesada

. Several factors have been shown to mediate leptin resistance at the central level: impaired leptin transport in the blood–brain barrier, endoplasmic reticulum stress, and impaired leptin signaling, among others ( Zhang et al . 2008 , Morris & Rui 2009

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Zodwa Dlamini, Fortunate Mokoena and Rodney Hull

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes . Diabetes 56 2016 – 2027 . ( doi:10.2337/db07-0197 ) 10

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Daniel Raleigh, Xiaoxue Zhang, Benoît Hastoy and Anne Clark

Gribble FM Altirriba J Knuutila S Novials A 2007 Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic