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K Lindberg, S G Rønn, D Tornehave, H Richter, J A Hansen, J Rømer, M Jackerott and N Billestrup

diabetes or even prevention of this disease. Thus it will be interesting in the future to try to dissect the effects of SOCS-3 on the different signal transduction pathways of the β-cell. Figure 1 In situ

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M J Waters, H N Hoang, D P Fairlie, R A Pelekanos and R J Brown

within the kinase-activation loop, hence JAK2 activation. JAK2 phosphorylation of selected receptor cytoplasmic domain tyrosine residues sets up binding sites for Src homology 2 (SH2) domain-containing proteins such as signal transduction and activators

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Ray-Jade Chen, His-Chin Wu, Mu-Hsin Chang, Chao-Hung Lai, Yun-Chen Tien, Jin-Ming Hwang, Wu-Hsien Kuo, Fuu-Jen Tsai, Chang-Hai Tsai, Li-Mien Chen, Chih-Yang Huang and Chun-Hsien Chu

signaling transduction in the heart remains unclear. In a variety of cardiovascular disorders, including myocardial infarction, cardiomyocytes apoptosis in the heart has been identified as key to heart failure ( Kang & Izumo 2000 , Grazette & Rosenzweig

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Sudipta Paul, Sourav Kundu, Kousik Pramanick, Arun Bandyopadhyay and Dilip Mukherjee

) and lead to the activation of multiple signal transduction pathways, including the adenylate cyclase-/cAMP-dependent protein kinase A (PKA) signaling pathway and calcium-/calmodulin-dependent pathways (see review in Leung & Steele (1992) and Van Der

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Anna Maria Di Blasio, Michele Vignali and Davide Gentilini

AEA ( Hillard & Jarrajan 2003 ) and endocytosis ( McFarland et al . 2004 ) have been hypothesised. Signal transduction and biological activity AEA and 2-AG exert most of their biological effects by binding to the cannabinoid receptors CB1 and CB2

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Michelle Colomiere, Michael Permezel and Martha Lappas

effects of obesity in pregnancy independently. Thus, the purpose of this study was to determine whether transduction of insulin-signalling pathway and glucose transport is hindered in maternal tissues from women with GDM (in the presence or absence of

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N Renlund, Y Jo, I Svechnikova, M Holst, D M Stocco, O Söder and K Svechnikov

RI being responsible for signal transduction ( Dinarello et al. 1989 ). Both of these receptors are expressed by the Leydig cells, Sertoli cells and macrophages in the testis ( Petersen et al. 2002 , Svechnikov et al. 2003 ). Recently

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Yue Wang, Xiu Long Niu, Xiao Qin Guo, Jing Yang, Ling Li, Ye Qu, Cun Xiu Hu, Li Qun Mao and Dan Wang

multiple signal transduction pathways such as JAK/STATs, MEK/ERK and PI3K/Akt pathways ( Hirano et al . 1997 ). The crosstalk between membrane-ER-induced intracellular signal transduction cascades and IL6-induced signal transduction pathways may include

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H Douglas Falls, Brian D Dayton, Dennis G Fry, Christopher A Ogiela, Verlyn G Schaefer, Sevan Brodjian, Regina M Reilly, Christine A Collins and Wiweka Kaszubska

activation of GHS-R by artificial GHSs showed a variety of responses such as an increase in intracellular cAMP and free Ca 2+ levels as well as activation of PKA and PKC ( Chen 2000 ). Recently, the ghrelin-stimulated GHS-R signal transduction pathway has

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J Gu, A Y S Law, B H Y Yeung and C K C Wong

Introduction Calcium ions have a variety of beneficial roles in living organisms. Their function is pleiotropic, ranging from the regulation of signaling cascades in a single cell to a wide variety of physiological functions at the organ level