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C-L Hsieh, Z Xie, Z-Y Liu, J E Green, W D Martin, M W Datta, F Yeung, D Pan and L W K Chung

A 2002 Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. Cancer Research 62 1862 –1867. Wang C , Iranmanesh A, Berman N, McDonald V, Steiner B, Ziel F, Faulkner SM, Dudley RE

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Xiaoting Jiang, Xin Ye, Wei Guo, Hongyun Lu and Zhanguo Gao

Hansen J Kristiansen K Debril MB Miard S Auwerx J 2002 The retinoblastoma–histone deacetylase 3 complex inhibits PPARγ and adipocyte differentiation . Developmental Cell 3 903 – 910 . ( doi:10.1016/S1534-5807(02)00360-X ). Ferrara A

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Diego Russo, Giuseppe Damante, Efisio Puxeddu, Cosimo Durante and Sebastiano Filetti

). The HDACi suberoylanilide hydroxamic acid (SAHA), also known as vorinostat, reportedly induced growth arrest and caspase-mediated apoptosis in ATC cells. These effects were mediated by increased p21 protein levels, retinoblastoma protein

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Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Eiji Kashiwagi, Takashi Dejima, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi and Seiji Naito

retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression . Journal of Clinical Investigation 120 4478 – 4492 . ( doi:10.1172/JCI44239 ). Shiota M Yokomizo A Naito S 2011a Increased androgen receptor

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Yoo Mee Kim, Juan Ji An, Yong-Jun Jin, Yumie Rhee, Bong Soo Cha, Hyun Chul Lee and Sung-Kil Lim

angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Research 54 3407

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Sucharitha Iyer and Sunita K Agarwal

Metabolism 100 E776 – E782 . ( https://doi.org/10.1210/jc.2015-1100 ) 10.1210/jc.2015-1100) Lin W Cao J Liu J Beshiri ML Fujiwara Y Francis J Cherniack AD Geisen C Blair LP Zou MR , et al . 2011 Loss of the retinoblastoma binding

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Fabio Luiz Fernandes-Rosa, Sheerazed Boulkroun and Maria-Christina Zennaro

retinoblastoma-associated Kruppel-associated box gene ( RBaK ), postmeiotic segregation increased 2 ( PMS2 ), guanine nucleotide-binding protein α-12 ( GNA12 ), replication protein A3 ( RPA3 ), zinc finger protein 12 ( ZNF12 ), glucocorticoid-induced transcript 1

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Jerzy-Roch Nofer

, peroxisome proliferator-activated receptor; Rb, retinoblastoma protein; ROS, reactive oxygen species; SOD, superoxide dismutase; SR-A, scavenger receptor type A; STAT, signal transducer and activator of transcription; TNF, tumor necrosis factor; TLR, toll

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Gabriele Capurso, Stefano Festa, Roberto Valente, Matteo Piciucchi, Francesco Panzuto, Robert T Jensen and Gianfranco Delle Fave

al . 1999 , Moore et al . 2001 b ), and the retinoblastoma TSG ( RB ) gene is also not implicated ( Chung et al . 1997 ). The p16 kinase inhibitor gene ( CDKN2A ), a TSG associated with familial melanoma, has been found to be inactivated in PETs

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Amanda M Ackermann and Maureen Gannon

retinoblastoma protein (Rb) by Cdk4/6 complexed with a D cyclin, which releases E2F allowing it to activate transcription of necessary cell cycle target genes. Thus, Cdk6 function is redundant with Cdk4; however, β-cells do not express detectable levels of Cdk6