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M J Moreno-Aliaga, M M Swarbrick, S Lorente-Cebrián, K L Stanhope, P J Havel and J A Martínez

, Moreno-Aliaga et al. 2002 ) and activators of peroxisome proliferator activated receptor (PPAR)-γ, such as thiazolidinediones ( De Vos et al. 1996 ). We have demonstrated previously that insulin-stimulated glucose metabolism, rather than a

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Fraydoon Rastinejad, Pengxiang Huang, Vikas Chandra and Sepideh Khorasanizadeh

in the liver ( Sladek et al . 1990 ). Targets of this receptor include genes involved in gluconeogenesis and lipid metabolism ( Yoon et al . 2001 , Bolotin et al . 2010 , Fang et al . 2012 ). In the pancreas, HNF-4α is believed to control some

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Gábor Bánhegyi, Miklós Csala and Angelo Benedetti

Introduction The aim of the present review is to summarize the recently discovered roles of hexose-6-phosphate dehydrogenase (H6PD) in the intermediary metabolism, redox homeostasis, and signaling of the cell. Although the enzyme has been known for

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Hyeon Young Park, Hye Suk Kang and Seung-Soon Im

maintenance of a steady-state level of membrane biosynthesis and coordinate many biological processes, such as cell growth and metabolic homeostasis ( Muro et al . 2014 , Shimano & Sato 2017 ). Cellular triglyceride homeostasis and cholesterol metabolism are

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Julika Lietzow, Janine Golchert, Georg Homuth, Uwe Völker, Wenke Jonas and Josef Köhrle

,5-diiodo-l-thyronine (3,5-T 2 ) ( Lehmphul et al. 2014 ), which has attracted scientific attention because of its marked effects on metabolism. In vivo and in vitro studies revealed that 3,5-T 2 stimulates hepatic fatty acid oxidation and increases

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Feng Wang, Xianfeng Zhang, Jiqiu Wang, Maopei Chen, Nengguang Fan, Qinyun Ma, Ruixin Liu, Rui Wang, Xiaoying Li, Mingyao Liu and Guang Ning

and lipid metabolism ( Le Martelot et al . 2009 ). A number of other genes, such as IRE1a , can influence metabolism at the posttranscriptional level ( Cretenet et al . 2010 ). To gain further insights into the mechanisms that coordinate the control

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Rebecca H Ritchie, Eser J Zerenturk, Darnel Prakoso and Anna C Calkin

overlooked, consequence of hyperglycaemia is the modulation of lipid metabolism. Diabetes is associated with impaired myocardial glucose uptake, and thus, there is an increased reliance on fatty acids (FA) as a source of adenosine triphosphate (ATP) in the

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Tingyuan Ren, Yuping Zhu, Xuejuan Xia, Yongbo Ding, Jing Guo and Jianquan Kan

Introduction As a global disease, diabetes mellitus seriously endangers human health. It is a glucose, fat and protein metabolism disorder caused by the absolute or relative deficiency in insulin secretion (Michaelides et al . 2016

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Heather C Denroche and C Bruce Verchere

aggregates form in T2D, and their precise role in disease pathogenesis remains unclear. In its monomeric form, IAPP may help regulate metabolism and satiety, though this biological role remains a matter of some debate. These properties of monomeric IAPP have

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Heather E Bergan, Jeffrey D Kittilson and Mark A Sheridan

Introduction Lipids play many roles in animals, but their most significant use is as an energy reserve; therefore, the breakdown of stored lipids (lipolysis) is a critical aspect of their metabolism ( Sheridan 1988 ). The main lipolytic enzyme is