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Laurent Léotoing, Michèle Manin, Didier Monté, Silvère Baron, Yves Communal, Corinne Lours, Georges Veyssière, Laurent Morel and Claude Beaudoin

were also characterised by a 90, 70 and 60% decrease in hyper-phosphorylated retinoblastoma (ppRb), p21 Cip1 and p53 proteins respectively. This decrease was associated with a parallel increase in the accumulation of the p27 Kip1 protein (Fig. 1b

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Amadeo Muñoz Garcia, Martina Kutmon, Lars Eijssen, Martin Hewison, Chris T Evelo and Susan L Coort

indicate that 1,25(OH) 2 D-regulated pathways were either cell specific or common to all three models. Pathways related to DNA replication, the cell cycle and cancer (retinoblastoma) showed high Z -scores and were more strongly regulated by 1,25(OH) 2 D in

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Stefania Carobbio, Barry Rosen and Antonio Vidal-Puig

to immortalise this cell line required infection with SV40 large T antigen, which binds retinoblastoma protein (pRB) and relieves the pRB control of the cell cycle ( Ali & DeCaprio 2001 ). pRB functions as a molecular switch driving cells towards the

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Chen-Lin Hsieh, Changmeng Cai, Ahmed Giwa, Aaronica Bivins, Shao-Yong Chen, Dina Sabry, Kumara Govardhan and Lirim Shemshedini

(CDK1) (Cell Signaling, Boston, MA, USA), CDK2 (Santa Cruz Biotechnology, Santa Cruz, CA, USA), CDK4 (Santa Cruz Biotechnology), cyclin D (Santa Cruz Biotechnology), retinoblastoma (Rb) (Cell Signaling), PSA (Biodesign, Carmel, NY, USA), p27 (Santa Cruz

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Maria Nygård, Nathalie Becker, Barbara Demeneix, Katarina Pettersson and Maria Bondesson

. 2004 ). The mechanism for suppression of proliferation by Necdin is similar to that of the retinoblastoma protein acting on E2F-1, namely that Necdin binds to E2F-1 in post-mitotic neurons and thereby blocks its activity ( Taniura et al. 1998 ). As

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Adrien Georges, Aurelie Auguste, Laurianne Bessière, Anne Vanet, Anne-Laure Todeschini and Reiner A Veitia

regulate the expression of FOXL2. One of them is FOXL2 itself, which binds to its promoter to activate its own transcription, at least in vitro ( Moumné et al . 2008 ). Another factor potentially regulating FOXL2 expression is retinoblastoma 1 (RB1). In

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Anne Wulf, Marianne G Wetzel, Maxim Kebenko, Meike Kröger, Angelika Harneit, Jennifer Merz and Joachim M Weitzel

thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis . Molecular and Cellular Biology 25 124 – 135 . Hashimoto K Yamada M Matsumoto S Monden T Satoh T Mori

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E J Gold, X Zhang, A M Wheatley, S L Mellor, M Cranfield, G P Risbridger, N P Groome and J S Fleming

first report of dynamic regulation of activin type IIB receptor subunit mRNA. The mechanisms by which activin A regulates hepatocyte growth arrest are largely unknown. In HepG2 cells, retinoblastoma hypophosphorylation – via modulation of p53, p

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Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang and Ming Dong

.1371/journal.pone.0042529 ) Zhang M Zhou YF Gong JY Gao CB Li SL 2016a Expression of autophagy-related protein LC3B, p62, and cytoplasmic p53 in human retinoblastoma tissues . European Review for Medical and Pharmacological Sciences

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Rui Takahashi, Hisamitsu Ishihara, Kazuma Takahashi, Akira Tamura, Suguru Yamaguchi, Takahiro Yamada, Hideki Katagiri and Yoshitomo Oka

. Journal Cell Biology 167 1123 –1135. Cozar-Castellano I , Takane KK, Bottino R, Balamurugan AN & Stewart AF 2004 Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using