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Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Eiji Kashiwagi, Takashi Dejima, Junichi Inokuchi, Katsunori Tatsugami, Takeshi Uchiumi and Seiji Naito

Introduction Prostate cancer is the most common non-cutaneous cancer and the second leading cause of cancer-related mortality in males in developed countries. For growth and survival, prostate cancer cells characteristically require androgens, which

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Momoe Itsumi, Masaki Shiota, Akira Yokomizo, Eiji Kashiwagi, Ario Takeuchi, Katsunori Tatsugami, Junichi Inokuchi, YooHyun Song, Takeshi Uchiumi and Seiji Naito

Introduction Prostate cancer is the most common non-cutaneous cancer and the second leading cause of cancer-related death of men in developed countries ( Siegel et al . 2012 ). Prostate-specific antigen (PSA) screening has improved early detection

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Chen-Lin Hsieh, Changmeng Cai, Ahmed Giwa, Aaronica Bivins, Shao-Yong Chen, Dina Sabry, Kumara Govardhan and Lirim Shemshedini

Introduction Prostate cancer is an epithelial-derived cancer ( Cussenot et al . 1994 ) that involves the action of androgens and androgen receptor (AR), a ligand-dependent transcription factor ( Chang et al . 1988 ). This liganded AR is essential

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Shen Gao, Hua Wang, Peng Lee, Jonathan Melamed, Caihong X Li, Fahao Zhang, Hong Wu, Liran Zhou and Zhengxin Wang

Introduction Androgens play a pivotal role in maintaining prostate homeostasis ( Denmeade et al. 1996 ) and under abnormal conditions they contribute to the development of prostate cancer ( Bentel & Tilley 1996 , Craft et al

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Silvia Ottaviani, Greg N Brooke, Ciara O'Hanlon-Brown, Jonathan Waxman, Simak Ali and Laki Buluwela

Introduction Androgens play a central role in the biology of normal prostate development and prostate cancer progression ( Shen & Abate-Shen 2010 ). These hormones mediate their effects through the action of the androgen receptor (AR), a member of

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Irene I Lee, Nane C Kuznik, Jaice T Rottenberg, Myles Brown and Andrew C B Cato

experimentally tested. BAG1L and prostate cancer The regulation of AR activity by BAG1L and the driver role of the AR in prostate cancer progression has generated an interest in the action of BAG1L in prostate cancer. A link between BAG1L and prostate

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Masaki Shiota, Akira Yokomizo and Seiji Naito

Introduction The androgen/androgen receptor (AR) signaling pathway is known to play a critical role in prostate tumorigenesis and prostate cancer (PCa) progression. Androgen-deprivation therapy (ADT) either reduces the production of androgens by

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Ke-Hung Tsui, Ying-Ling Chang, Tsui-Hsia Feng, Li-Chuan Chung, Tzu-Yi Lee, Phei-Lang Chang and Horng-Heng Juang

-β), nonsteroidal anti-inflammatory drug-activated gene-1, and prostate differentiation factor ( Bootcov et al . 1997 , Hromas et al . 1997 , Paralkar et al . 1998 ). GDF15 is a secretory dimeric protein that bears the structural characteristics of cytokines in

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Lai Jin, Qichun Zhang, Rui Guo, Lina Wang, Juejin Wang, Rong Wan, Rongjian Zhang, Youhua Xu and Shengnan Li

date, few investigations have been reported on CRF family and prostatic tumor. Ucn, which was first detected in prostatic adenocarcinoma by RT-PCR and immunohistochemistry ( Arcuri et al . 2002 ), is speculated to be related to prostate tumorigenesis

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See-Tong Pang, Wen-Chi Hsieh, Cheng-Keng Chuang, Chun-Hsiang Chao, Wen-Hui Weng and Horng-Heng Juang

proliferation ( Song et al . 2003 ). TXNIP function and gene regulation in human prostate cells require further clarification. Early studies have indicated that TXNIP expression is negatively regulated by androgens in murine prostate cells ( Pang et al . 2002