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Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Hong Li and Fenping Zheng

.01. LXR activation promotes adipocyte apoptosis and inflammation in epididymal fat To clarify whether the morphological changes in adipose tissue of T0901317-treated mice were associated with decreased cell numbers, apoptotic cells in the adipose tissue

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Robert Lee Stanley, Takako Ohashi, Jacob Gordon and Chishimba Nathan Mowa

capacity of neutrophils and macrophages during inflammation and wound healing ( Witke et al . 1996 ). Also, gelsolin has been clinically associated with a variety of impairments in inflammation, cell invasion, immune cell recruitment and wound healing

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Srividya Vasu, R Charlotte Moffett, Neville H McClenaghan and Peter R Flatt

diabetes ( Kappe et al . 2014 ). In the context of type 1 diabetes pathogenesis, such disturbances may contribute to the observed metabolic abnormalities. Indeed, although pancreatic β-cell death is mediated by local inflammation, elevated systemic levels

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Guojun Shi, Chen Sun, Weiqiong Gu, Minglan Yang, Xiaofang Zhang, Nan Zhai, Yan Lu, Zhijian Zhang, Peishun Shou, Zhiguo Zhang and Guang Ning

fibers and carbohydrates in the intestinal tract ( Bindels et al . 2013 ). In addition to being minor nutrient sources in humans, SCFAs are also emerging as a class of signaling molecules in inflammation and metabolic processes ( Layden et al . 2013

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Aurelie Nguyen Dinh Cat, Malou Friederich-Persson, Anna White and Rhian M Touyz

that the dysregulation of CTRP-1 levels in obesity is strongly associated with chronic inflammation in adipose tissue ( Kim et al . 2006 ). Additionally, patients with metabolic syndrome and type 2 diabetes have increased circulating levels of CTRP-1

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Yanjun Cui and Xianhong Gu

, investigations have been focused on mechanisms underlying the effect of acute HS on intestinal function and integrity. Acute HS causes hypoxia and inflammation of the intestinal epithelium ( Lambert 2009 , Qi et al . 2011 ), both of which regulate intestinal

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L Y Ching, Bonnie H Y Yeung and Chris K C Wong

inflammation and carcinogenesis ( Wagner et al . 1997 , Madsen et al . 1998 , Chang et al . 2003 , Yoshiko & Aubin 2004 , Ellard et al . 2007 , Re & Cook 2010 , Sheikh-Hamad 2010 ). Cancer has been considered as a chronic inflammatory disease ( Lopez

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M Blumenstein, J A Keelan, J M Bowen-Shauver and M D Mitchell

SOCS proteins in gestational tissues with term labor, and hypothesized that a decrease in SOCS proteins in the term placenta could be part of the mechanism facilitating labor-associated inflammation, or part of a feed-forward mechanism for amplification

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Chunyu Wang, Li Tian, Kun Zhang, Yaxi Chen, Xiang Chen, Ying Xie, Qian Zhao and Xijie Yu

secretion, such as leptin and adiponectin, which might exert a direct effect on bone formation or indirect effect on bone resorption. Furthermore, obesity is related to a chronic inflammation condition. Increase in circulating and tissue proinflammatory

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Juan Liu, Xiaocen Kong, Long Wang, Hanmei Qi, Wenjuan Di, Xiao Zhang, Lin Wu, Xia Chen, Jing Yu, Juanmin Zha, Shan Lv, Aisen Zhang, Peng Cheng, Miao Hu, Yujie Li, Jianhua Bi, Yan Li, Fang Hu, Yi Zhong, Yong Xu and Guoxian Ding

, Staab & Maser 2010 ). Besides, we recently found that BVT.2733, a selective 11β-HSD1 inhibitor, could even attenuate the inflammation of WAT in diet-induced obese mice ( Wang et al . 2012 ). However, the role of 11β-HSD1 in BAT remains largely unknown