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Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Hong Li, and Fenping Zheng

.01. LXR activation promotes adipocyte apoptosis and inflammation in epididymal fat To clarify whether the morphological changes in adipose tissue of T0901317-treated mice were associated with decreased cell numbers, apoptotic cells in the adipose tissue

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Guojun Shi, Chen Sun, Weiqiong Gu, Minglan Yang, Xiaofang Zhang, Nan Zhai, Yan Lu, Zhijian Zhang, Peishun Shou, Zhiguo Zhang, and Guang Ning

fibers and carbohydrates in the intestinal tract ( Bindels et al . 2013 ). In addition to being minor nutrient sources in humans, SCFAs are also emerging as a class of signaling molecules in inflammation and metabolic processes ( Layden et al . 2013

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Srividya Vasu, R Charlotte Moffett, Neville H McClenaghan, and Peter R Flatt

diabetes ( Kappe et al . 2014 ). In the context of type 1 diabetes pathogenesis, such disturbances may contribute to the observed metabolic abnormalities. Indeed, although pancreatic β-cell death is mediated by local inflammation, elevated systemic levels

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Jingyi Luo, Tingting Liu, and Weiping Teng

form lymphoid follicles ( Antonelli et al. 2015 ). The cells infiltrating the thyroid gland are mainly T cells, especially CD4 + T cells, which are directly related to inflammation and thyroid cell destruction ( Luty et al. 2019 ). Pro

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He-jun Zhao, Xia Jiang, Li-juan Hu, Lei Yang, Lian-dong Deng, Ya-ping Wang, and Zhi-peng Ren

treatment subsequently led to the attenuation of ovalbumin-induced airway inflammation ( Zhu et al . 2015 ). In fact, NF-κB is not only an important transcription factor in inflammation, immune response, cell proliferation, and apoptosis ( Baker et al

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Yanjun Cui and Xianhong Gu

, investigations have been focused on mechanisms underlying the effect of acute HS on intestinal function and integrity. Acute HS causes hypoxia and inflammation of the intestinal epithelium ( Lambert 2009 , Qi et al . 2011 ), both of which regulate intestinal

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Aurelie Nguyen Dinh Cat, Malou Friederich-Persson, Anna White, and Rhian M Touyz

that the dysregulation of CTRP-1 levels in obesity is strongly associated with chronic inflammation in adipose tissue ( Kim et al . 2006 ). Additionally, patients with metabolic syndrome and type 2 diabetes have increased circulating levels of CTRP-1

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Rihua Zhang, Dongming Su, Weidong Zhu, Qiong Huang, Menglan Liu, Yi Xue, Yuanyuan Zhang, Dong li, Allan Zhao, and Yun Liu

models have shown that oophorectomy results in obesity, altered fat distribution, adipose tissue inflammation, and development of fatty liver ( Rogers et al . 2009 , Stubbins et al . 2012 ). Estrogen therapy is believed to have beneficial effects on

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Juan Liu, Xiaocen Kong, Long Wang, Hanmei Qi, Wenjuan Di, Xiao Zhang, Lin Wu, Xia Chen, Jing Yu, Juanmin Zha, Shan Lv, Aisen Zhang, Peng Cheng, Miao Hu, Yujie Li, Jianhua Bi, Yan Li, Fang Hu, Yi Zhong, Yong Xu, and Guoxian Ding

, Staab & Maser 2010 ). Besides, we recently found that BVT.2733, a selective 11β-HSD1 inhibitor, could even attenuate the inflammation of WAT in diet-induced obese mice ( Wang et al . 2012 ). However, the role of 11β-HSD1 in BAT remains largely unknown

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M Blumenstein, J A Keelan, J M Bowen-Shauver, and M D Mitchell

SOCS proteins in gestational tissues with term labor, and hypothesized that a decrease in SOCS proteins in the term placenta could be part of the mechanism facilitating labor-associated inflammation, or part of a feed-forward mechanism for amplification