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Michelle Mohyi and Terry J Smith

serious consideration. Figure 1 Facial portrait of a patient with relatively mild, asymmetric thyroid-associated ophthalmopathy. The patient manifests bilateral upper eyelid retraction, periorbital swelling and mild conjunctival inflammation

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Jun Zhou, Qilong Wang, Ye Ding and Ming-Hui Zou

adipose tissue. Insulin resistance is partly caused by chronic low-level inflammation and oxidative stress in adipose tissue ( Guo 2014 ). Infiltration of inflammatory cells, which produce cytokines and oxidants, leads to a local inflammatory environment

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Bo Zhou, Huixia Li, Jiali Liu, Lin Xu, Qinyue Guo, Hongzhi Sun and Shufang Wu

-deficient mice exhibited resistance to diet-induced obesity and insulin insensitivity through the modulation of inflammation, whereas adipocytes exposed to PGRN have increased susceptibility to be insulin-resistant and those effects can be normalized with

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Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan

have resulted in the remarkably increased plasma AST level of TRIB1 overexpression ( Table 1 ). The relatively mild AST increase in mice with TRIB1 knockdown and those injected with the LacZ vector might have resulted from inflammation induced by

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Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu and Bo Yu

, cardiomyopathy, exhibiting as cardiac structural remodeling and dysfunction in terms of abnormal energy metabolism, myocardial inflammation and impaired left ventricular contractility, leads to unhealthy outcome in obese patients ( Alpert et al. 2014

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S Dubois, A M Madec, A Mesnier, M Armanet, K Chikh, T Berney and Ch Thivolet

and proteins were extracted, except for HUVECs where only RNA was extracted. Real-time PCR and/or protein arrays evaluated markers involved in inflammation, and angiogenesis was performed. Media from pancreatic islet cultures were kept frozen and

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Z Alourfi, R P Donn, A Stevens, A Berry, A McMaster and D W Ray

immunoreactivity has also been described within sites of inflammation including those of inflammatory arthritis, colitis and psoriatic skin lesions (reviewed by ( Nishihira 1998 , Lue et al. 2002 ). A direct role for MIF in the aetiology of the inflammatory

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Patrizia Morera, Loredana Basiricò, Kenji Hosoda and Umberto Bernabucci

(e.g. endotoxins) from the gastrointestinal lumen to the blood. Endotoxins entering the blood stream may induce the development of inflammation by stimulating the secretion and release of a variety of pro-inflammatory factors ( Lambert et al . 2002

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Dawn X Zhang and Christopher K Glass

immunity and normal homeostatic processes, macrophages are essential to the body's ability to control inflammation. Consequently, these immune cells have been implicated in multiple disease processes such as diabetes, rheumatoid arthritis, multiple

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C Folgueira, S Barja-Fernandez, P Gonzalez-Saenz, V Pena-Leon, C Castelao, M Ruiz-Piñon, F F Casanueva, R Nogueiras and L M Seoane

associated with endoplasmic reticulum (ER) stress ( Kim et al . 2016 ). In line with this observation, a recent study has found that inflammation correlates with decreased circulating proUGN levels female adolescents with obesity ( Di Guglielmo et al . 2017