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Sofia A Rahman, Azizun Nessa and Khalid Hussain

inappropriate release leads to persistent hyperinsulinaemic hypoglycaemia (HH). This drives glucose into the insulin sensitive tissues and simultaneously suppresses lipolysis and ketogenesis. The combined hypoketonaemic and hypoglycaemic characteristic of CHI

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Fumihiko Hakuno and Shin-Ichiro Takahashi

, lipolysis and protein degradation. IGFs predominantly mediate long-term action to determine the cell fates, whereas insulin mainly possesses metabolic activity. Despite the profuseness and diversity of these effects of IGFs, the in vitro biological

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Zhigang Hu, Wen-Jun Shen, Fredric B Kraemer and Salman Azhar

Kraemer FB 2001 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway . Journal of Biological Chemistry 276 45456 – 45461 . ( doi:10.1074/jbc.M104436200 ) 10.1074/jbc.M104436200 Hiort O

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Keir Menzies and Johan Auwerx

reliant on substrates that drive OXPHOS activity. Lipids, which can be oxidized by mitochondria, are provided by lipolysis in adipose tissue and of intramuscular triacylglycerols. Carbohydrates, in the form of glucose, can be sequestered from the

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Cristina Velasco, Cristina Otero-Rodiño, Sara Comesaña, Jesús M Míguez and José L Soengas

-inhibited adipocyte lipolysis . Comparative Biochemistry and Physiology A 204 76 – 84 . ( doi:10.1016/j.cbpa.2016.11.011 ) 10.1016/j.cbpa.2016.11.011 Tang Z Sun C Yan A Wu S Qin C Zhang Y Li W 2013 Genes involved in fatty acid

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Dimitrios Doultsinos and Ian Mills

Teesch LM , 2017 ER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis . Cell Reports 19 1794 – 1806 . ( https://doi.org/10.1016/j.celrep.2017

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Weiwei Fan, Annette R Atkins, Ruth T Yu, Michael Downes and Ronald M Evans

Journal 27 4004 – 4016 . ( doi:10.1096/fj.13-228296 ). Maxwell MA Cleasby ME Harding A Stark A Cooney GJ Muscat GE 2005 Nur77 regulates lipolysis in skeletal muscle cells – evidence for cross-talk between the β-adrenergic and an orphan

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Anthony H Tsang, Johanna L Barclay and Henrik Oster

gluconeogenesis in liver and lipolysis in adipose tissues ( Kwon & Hermayer 2013 ). GCs also play an important role in modulating immune ( Silverman & Sternberg 2012 ) and cognitive functions ( Sandi 2011 ). The majority of the effects of GCs are mediated by its

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Rebecca H Ritchie, Eser J Zerenturk, Darnel Prakoso and Anna C Calkin

al . 2008 ). Plasma TAG levels were increased by ~70% and cardiac TAG and DAG levels were both significantly elevated in diabetic mice. Interestingly, key genes involved in the regulation of lipid uptake, oxidation, FA release, lipolysis and uptake

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Shambhunath Bose, M Abul Farah, Ho-Chul Jung, Jeong-Heon Lee and Yangsun Kim

oxidation, glycogen synthesis, and lipogenesis in addition to the inhibition of lipolysis and gluconeogenesis (reviewed by Srivastava & Mehdi 2005 ). Cumulative reports suggest that vanadium can trigger the activation of many components of insulin signaling