Search Results

You are looking at 101 - 110 of 357 items for :

  • inflammation x
Clear All
Free access

Gábor Bánhegyi, Miklós Csala and Angelo Benedetti

the accumulation of immature proteins and triggers the unfolded protein response (UPR) that finally leads to a variety of downstream effects, such as apoptosis, inflammation, and insulin resistance ( Hotamisligil 2005 , Yoshida 2007 , Zhang & Kaufman

Open access

Gillian A Gray, Christopher I White, Raphael F P Castellan, Sara J McSweeney and Karen E Chapman

/macrophages and neutrophils regulates their recruitment to sites of inflammation ( Tiganescu et al. 2011 ), phagocytic potential ( Speirs et al. 2004 ) and the release of pro-inflammatory molecules ( Zhang & Daynes 2007 ). 11β-HSD1 inhibition may therefore be

Free access

Lichun Zhou, Baohua Ma and Xiuzhen Han

) Cardiac hypertrophy LC-3 II/I ratio and mitophagy decreased Macrophages from wild-type C57BL/6J or Atg5 +/− mice 1 μmol/L Ang II (48 h) Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury Zhao et al . (2014

Free access

Andrew Whittle

certainly supported by functional data from humans ( McQuaid et al . 2011 ). These non-adipose tissues are poorly adapted for fat storage and as such succumb to lipotoxic effects that lead to increased insulin resistance, inflammation and apoptosis ( Virtue

Free access

Ahter D Sanlioglu, Bahri Karacay, Mustafa Kemal Balci, Thomas S Griffith and Salih Sanlioglu

Obesity and inflammation Diabetes is the third most common disease and fourth leading cause of death in the world ( Tabak et al . 2012 ). Insulin resistance, impaired glucose tolerance, and excessive glucagon secretion are the prominent features of

Free access

Edward T Bagu and Manuela M Santos

. 2010 ). Increases in the concentration of iron and inflammation upregulate the transcription of hepcidin, while iron deficiency and hypoxia downregulate it ( Nicolas et al . 2002 ). At present, it is unclear as to what the molecular mechanisms involved

Free access

Michelle Mohyi and Terry J Smith

serious consideration. Figure 1 Facial portrait of a patient with relatively mild, asymmetric thyroid-associated ophthalmopathy. The patient manifests bilateral upper eyelid retraction, periorbital swelling and mild conjunctival inflammation

Free access

Xinwang Chen, Xiao Jia, Jie Qiao, Youfei Guan and Jihong Kang

, and IL1β, are best known for their association with inflammation and have been reviewed in detail elsewhere ( Bohler et al . 2010 ). Leptin Named from the Greek leptos (meaning thin), leptin is a 167-amino acid protein encoded by the ob gene. It

Free access

Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan

have resulted in the remarkably increased plasma AST level of TRIB1 overexpression ( Table 1 ). The relatively mild AST increase in mice with TRIB1 knockdown and those injected with the LacZ vector might have resulted from inflammation induced by

Free access

Bo Zhou, Huixia Li, Jiali Liu, Lin Xu, Qinyue Guo, Hongzhi Sun and Shufang Wu

-deficient mice exhibited resistance to diet-induced obesity and insulin insensitivity through the modulation of inflammation, whereas adipocytes exposed to PGRN have increased susceptibility to be insulin-resistant and those effects can be normalized with