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Bethany Hart, Elizabeth Morgan and Emilyn U Alejandro

RG Knowler WC 1991 Abnormal glucose tolerance during pregnancy in Pima Indian women. Long-term effects on offspring . Diabetes 40 ( Supplement 2 ) 126 – 130 . ( ) 1748241 10.2337/diab.40.2.S126 Proud

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Rhonda D Kineman, Mercedes del Rio-Moreno and André Sarmento-Cabral

1R signaling is required to maintain normal β-cell function, based on reports showing rat insulin promoter 2-Cre mice crossbred to two different models of Igf1r fl/fl mice, exhibit impaired glucose tolerance, without influencing β-cell mass

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Jiayu Jin, Xinhong Wang, Xiuling Zhi and Dan Meng

. 2016 ). In addition, the suppression of MEG3 expression was linked with compromised glucose tolerance and impaired insulin secretion ( You et al. 2016 ). Correspondingly, the overexpression of MEG3 has been demonstrated to ameliorate diabetic

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Sumaira Z Hasnain, Johannes B Prins and Michael A McGuckin

& Metabolism 10 ( Suppl 4 ) 32 – 42 . ( doi:10.1111/j.1463-1326.2008.00969.x ). Rissanen A Howard CP Botha J Thuren T 2012 Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes

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Gemma Tan, Andrew G Elefanty and Edouard G Stanley

Wolters GH Van Schilfgaarde R 1991 Glucose tolerance and plasma insulin response to intravenous glucose infusion and test meal in rats with microencapsulated islet allografts . Diabetologia 34 542 – 547 . ( doi:10.1007/BF00400270

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Edra London, Maria Nesterova and Constantine A Stratakis

protein, fat and carbohydrate. Weight gain, adiposity and glucose tolerance Mice were weighed at baseline and then weekly at 09:00 h during the experimental period and at time of killing. Body composition was measured at the conclusion of the 14

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R Serrano, M Villar, C Martínez, J M Carrascosa, N Gallardo and A Andrés

classically associated with impaired glucose tolerance and/or peripheral insulin resistance ( De Fronzo 1981 , Narimiya et al. 1984 ). Aged Wistar rats are characterized by fasting normoglycemia and normoinsulinemia and show overall insulin resistance as

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C Folgueira, S Barja-Fernandez, P Gonzalez-Saenz, V Pena-Leon, C Castelao, M Ruiz-Piñon, F F Casanueva, R Nogueiras and L M Seoane

2C-knockout mice had unaltered body weight, adiposity and glucose tolerance ( Begg et al . 2014 ). Therefore, the physiological significance of the UGN-GUCY2C system for the control of energy homeostasis is not fully understood

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Talitha van der Meulen and Mark O Huising

partially compensate for the loss of MAFA ( Artner et al . 2010 ). Nevertheless, these mice display reduced expression of several genes involved in glucose-stimulated insulin secretion and have reduced glucose tolerance ( Zhang et al . 2005 , Artner et

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Keir Menzies and Johan Auwerx

et al . 2010 , Schenk et al . 2011 , Fernandez-Marcos et al . 2012 ). Interestingly, the NAD + intermediate, nicotinamide mononucleotide (NMN), can restore NAD + levels and improve glucose tolerance in high fat diet (HFD)-induced diabetic mice