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Riccarda Granata, Alessandra Baragli, Fabio Settanni, Francesca Scarlatti and Ezio Ghigo

. Such mice showed reduced glucose-stimulated insulin secretion and lower blood glucose levels and triglyceride levels during insulin tolerance test. Insulin secretion from isolated islets was instead indistinguishable from that of nontransgenic

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Elin Swedenborg, Joëlle Rüegg, Sari Mäkelä and Ingemar Pongratz

syndrome or syndrome X is a term for a combination of disorders that may include impaired glucose tolerance or insulin resistance, dyslipidemia, high blood pressure, and obesity (reviewed in Despres et al . (2008) and Phillips & Prins (2008) ). Key

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M Blandino-Rosano, G Perez-Arana, J M Mellado-Gil, C Segundo and M Aguilar-Diosdado

cells . Diabetologia 47 478 – 487 . Xu G Stoffers DA Habener JF Bonner-Weir S 1999 Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats . Diabetes 48

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Louise K Metcalfe, Greg C Smith and Nigel Turner

, particularly in studies demonstrating the beneficial effects of their deficiency. The genetic ablation of sphingomyelin synthase 2 ( Sms2 ), for instance, has been found in HFD-fed rodents to improve whole-body insulin sensitivity, glucose tolerance and weight

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Xiaoting Jiang, Xin Ye, Wei Guo, Hongyun Lu and Zhanguo Gao

differentiated 3T3-L1 adipocytes were treated with H3I overnight, and then glucose uptake was measured. *Drug vs control; # drug+insulin vs insulin; P <0.05 by Student's t -test. H3I, HDAC3 inhibitor. (B) Insulin signaling. (C) Insulin tolerance test. (D) Area

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Irit Hochberg, Innocence Harvey, Quynh T Tran, Erin J Stephenson, Ariel L Barkan, Alan R Saltiel, William F Chandler and Dave Bridges

sensitivity, we performed insulin tolerance tests on these mice after 12 weeks of dexamethasone treatment and found that while they had reduced fasting glucose at this stage, they were resistant to insulin-induced reductions in blood glucose ( Fig. 2 E). On

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H Roger Lijnen and Ilse Scroyen

, several studies have suggested a link between the VEGF/VEGF-R2 pathway and insulin sensitivity and glucose tolerance ( Elias et al . 2012 , Wada et al . 2010 ). In this study, we have investigated whether DC101, a VEGF-R2 blocking MAB ( Bocci et al

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Ciro Menale, Maria Teresa Piccolo, Grazia Cirillo, Raffaele A Calogero, Alfonso Papparella, Luigi Mita, Emanuele Miraglia Del Giudice, Nadia Diano, Stefania Crispi and Damiano Gustavo Mita

hypothesize that BPA could influence PI3K/Akt signaling. The data of this study agrees well with previous studies that show that GPR30 knockout mice displayed impaired glucose tolerance, reduced body growth, and increased body weight ( Martensson et al . 2009

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Shadab Abadpour, Bente Halvorsen, Afaf Sahraoui, Olle Korsgren, Pål Aukrust and Hanne Scholz

days. Transplanted human islets response to glucose was analyzed by performing oral glucose tolerance test (OGTT) on day 15 after 1st graft removal (Supplementary Fig. 1, see section on supplementary data given at the end of this article). At

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Loes P M Duivenvoorde, Evert M van Schothorst, Annelies Bunschoten and Jaap Keijer

restricted (30%) or ad libitum (HF-AL) basis. We show that, although an animal is fed a HF (western) diet, the moderate reduction in the total amount of calories improves metabolic health, as measured by a number of parameters, such as glucose tolerance and