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T Traboulsi, M El Ezzy, J L Gleason and S Mader

development have led to the development and clinical use of small synthetic molecules that block either estrogen production (aromatase inhibitors) or estrogenic signaling (antiestrogens, AEs). AEs are steroids or steroid mimics that compete with endogenous

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Prasenjit Dey, Rodrigo P A Barros, Margaret Warner, Anders Ström and Jan-Åke Gustafsson

action of the enzyme aromatase, there is another class of estrogens which do not have an aromatic A-ring. These are 5-androstene-3β,17β-diol (A 5 diol), synthesized from the adrenal steroid dehydroepiandrosterone, and 5α-androstane-3β,17β-diol (3β

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L Y Zhou, D S Wang, B Senthilkumaran, M Yoshikuni, Y Shibata, T Kobayashi, C C Sudhakumari and Y Nagahama

growth and vitellogenesis, which is consistent to the putative function attributed for cytochrome P450 aromatase ( Yoshiura et al. 2003 ). In teleosts, the production of steroids in ovary follows the classical two cell type model system ( Nagahama 2000

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K Raghuveer and B Senthilkumaran

Dynamics 237 297 – 306 . Kwon JY McAndrew BJ Penman DJ 2001 Cloning of brain aromatase gene and expression of brain and ovarian aromatase genes during sexual differentiation in genetic male and female Nile tilapia Oreochromis niloticus

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Ann Lo, Weiming Zheng, Yimei Gong, John R Crochet and Lisa M Halvorson

, stimulate expression of multiple gonadal genes including StAR, aromatase (CYP19), inhibin α-subunit, and Müllerian-inhibiting substance (MIS) genes, both alone and in synergy with SF-1 ( Watanabe et al . 2000 , Tremblay & Viger 2001 , Tremblay et al

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F M Fioretti, A Sita-Lumsden, C L Bevan and G N Brooke

degradation, through the use of anti-oestrogens, or blocks oestrogen synthesis with aromatase inhibitors (AIs). Two distinct classes of synthetic anti-oestrogens have been developed: selective ER modulators (SERMs) and selective ER downregulators (SERDs

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Silvia Giatti, Mariaserena Boraso, Roberto Cosimo Melcangi and Barbara Viviani

into testosterone, or into androstenedione in all the cells of the CNS ( Melcangi et al . 2008 ). In neurons, androstenedione, as well as testosterone, may be converted by the enzyme P450 aromatase (ARO) to estrone and 17β-estradiol (17β-E 2

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K A Brown, D Boerboom, N Bouchard, M Doré, J G Lussier and J Sirois

cytochrome P450 17α-hydroxylase/17,20-lyase and aromatase, which are key enzymes involved in androgen and estrogen biosynthesis, and the increase in steroidogenic acute regulatory protein and cytochrome P450 cholesterol side-chain cleavage expression, which

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Mayumi Yoshioka, André Boivin, Carl Bolduc and Jonny St-Amand

testosterone and estrogen throughout life. Circulating testosterone is also a prohormone, which can be converted to the biologically active hormone dihydrotestosterone (DHT) by 5α -reductase or to estradiol by aromatase. Testosterone levels decline with age in

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Yukinori Kazeto, Rie Goto-Kazeto, Peter Thomas and John M Trant

. Kazeto Y , Goto-Kazeto R, Place AR & Trant JM 2004 Aromatase (CYP19A2) in zebrafish and channel catfish brains: Changes in expression associated with the reproductive cycle and endocrine disrupting chemicals. Fish Physiology and Biochemistry 28