Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Ling Cheng x
  • Refine by access: All content x
Clear All Modify Search
Zhiyu Ma College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Zhiyu Ma in
Google Scholar
PubMed
Close
,
Ying Zhang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ying Zhang in
Google Scholar
PubMed
Close
,
Juan Su College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Juan Su in
Google Scholar
PubMed
Close
,
Sheng Yang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Sheng Yang in
Google Scholar
PubMed
Close
,
Wenna Qiao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenna Qiao in
Google Scholar
PubMed
Close
,
Xiang Li College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Xiang Li in
Google Scholar
PubMed
Close
,
Zhihai Lei College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Zhihai Lei in
Google Scholar
PubMed
Close
,
Ling Cheng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ling Cheng in
Google Scholar
PubMed
Close
,
Na An College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Na An in
Google Scholar
PubMed
Close
,
Wenshao Wang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenshao Wang in
Google Scholar
PubMed
Close
,
Yanyan Feng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Yanyan Feng in
Google Scholar
PubMed
Close
, and
Jinlong Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Jinlong Zhang in
Google Scholar
PubMed
Close

Neuromedin B (NMB), a mammalian bombesin-related peptide, has numerous physiological functions, including regulating hormone secretions, cell growth, and reproduction, by binding to its receptor (NMBR). In this study, we investigated the effects of NMB on testosterone secretion, steroidogenesis, cell proliferation, and apoptosis in cultured primary porcine Leydig cells. NMBR was mainly expressed in the Leydig cells of porcine testes, and a specific dose of NMB significantly promoted the secretion of testosterone in the primary Leydig cells; moreover, NMB increased the expression of mRNA and/or proteins of NMBR and steroidogenic mediators (steroidogenic acute regulatory (STAR), CYP11A1, and HSD3B1) in the Leydig cells. In addition, specific doses of NMB promoted the proliferation of Leydig cells and increased the expression of proliferating cell nuclear antigen and Cyclin B1 proteins, while suppressing Leydig cell apoptosis and decreasing BAX and Caspase-3 protein expression. These results suggest that the NMB/NMBR system might play an important role in regulating boar reproductive function by modulating steroidogenesis and/or cell growth in porcine Leydig cells.

Free access